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Table 3 Comparison of patient characteristics

From: Low-level laser therapy in treatment of chemoradiotherapy-induced mucositis in head and neck cancer: results of a randomised, triple blind, multicentre phase III trial

   No LLLT/PBMT
(n = 32)
LLLT/PBMT
(active or placebo)
(n = 51)
p-value
Gender Female 6 (18.8%) 2 (3.9%) 0.05006
  Male 26 (81.3%) 49 (96.1%)  
Age (years) Mean ± SD 57.5 (52.7–64.5) 59 (53–65) 0.97
Tumour Location Oral cavity 8 (25%) 9 (17.6%) 0.60
  Hypopharynx 8 (25.0%) 11 (21.6%)  
Oropharynx 16 (50.0%) 31 (60.8%)  
TNM classification T1 5 (15.6%) 2 (3.9%) 0.20
  T2 8 (25.0%) 16 (31.4%)  
T3 10 (31.2%) 24 (47.1%)  
T4a 7 (21.9%) 6 (11.8%)  
T4b 2 (6.2%) 3 (5.9%)  
N0 3 (9.4%) 12 (23.5%) 0.25
N1 3 (9.4%) 3 (5.9%)  
N2 24 (75.0%) 32 (62.7%)  
N3 1 (3.1%) 4 (7.8%)  
Nx 1 (3.1%) 0 (0%)  
Histologic differentiation Well-differentiated 15 (46.9%) 21 (41.2%) 0.95
  Unknown 2 (6.3%) 4 (7.8%)  
Moderately differentiated 12 (37.5%) 19 (37.3%)  
Poorly differentiated 3 (9.4%) 7 (13.7%)  
Smoking status Never-smokers 4 (12.5%) 8 (15.7%) 0.94
  Smokers 28 (87.5%) 43 (84.3%)  
During CRT Smoking cessation 1 (7.7%) 7 (38.9%) 0.095
  Active smokers 12 (92.3%) 11 (61.1%)  
Alcohol consumption No 9 (28.1%) 13 (25.5%) 0.64
  Unknown 2 (6.3%) 1 (2.0%)  
Yes 21 (65.6%) 37 (72.5%)  
During CRT Alcohol withdrawal 3 (33.3%) 5 (25.0%) 0.99
  Active alcohol use 6 (66.7%) 15 (75.0%)  
Feeding Enteral feeding 4 (12.5%) 5 (9.8%) 0.84
  Liquid diet 0 (0%) 1 (2.0%)
Minced food 7 (21.9%) 16 (31.4%) (binary
Unspecified 2 (6.3%) 0 (0%) data)
Solid diet 19 (59.4%) 29 (56.9%)  
  1. TNM Tumour/Node/Metastasis.
  2. CRT Chemoradiotherapy.