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Table 1 Model fitting results of in vitro measurements of the change in the radiosensitivity of cancer cell cultures after exposure to fractionated radiation. Effect of different fractionation regimens on the mean α/β ratio and SF2 value. For each cell line the corresponding reference of the study is provided as superindexes

From: Modeling the effect of intratumoral heterogeneity of radiosensitivity on tumor response over the course of fractionated radiation therapy

Cell Line

Total Dose

Number of Fractions

α/β before treatment

α/β end of streatment

SF2 before treatment

SF2 end of treatment

PC3 31

10 Gy

5

22.1 ± 7.0 Gy

16.6 ± 6.2 Gy

0.40 ± 0.09

0.50 ± 0.10

LNCaP 31

10 Gy

5

18.0 ± 6.5 Gy

12.5 ± 5.9 Gy

0.47 ± 0.10

0.58 ± 0.12

Du145 31

10 Gy

5

15.5 ± 6.3 Gy

10.1 ± 5.5 Gy

0.52 ± 0.11

0.64 ± 0.12

A549 32

16 Gy

8

10.2 ± 3.3 Gy

5.4 ± 2.7 Gy

0.44 ± 0.10

0.61 ± 0.11

H460 32

26 Gy

13

3.1 ± 1.1 Gy

1.2 ± 0.8 Gy

0.46 ± 0.08

0.61 ± 0.07

OE33 30

50 Gy

25

20.6 ± 5.1 Gy

13.7 ± 3.2 Gy

0.42 ± 0.05

0.56 ± 0.04