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Fig. 7 | Radiation Oncology

Fig. 7

From: Modeling the effect of intratumoral heterogeneity of radiosensitivity on tumor response over the course of fractionated radiation therapy

Fig. 7

Radiotherapy response of tumors with more rapidly and slowly growing resistant cells. a, c Non-uniform distribution of daily repopulation rates, (a, b) rapidly and (c, d) slowly growing resistant cells, within a tumor as in Fig. 4c. Parameters in Eq. (4) were μ = 0.3 and θ = 5.5. b, d Tumor cell survival to BED-equivalent fractionations at 2.0 Gy/day in 25 fractions and 3.0 Gy/day in 15 fractions both with weekend interruptions. Results were obtained for a uniform repopulation of 15% and the non-uniform repopulation distributions as in (a, c)

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