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Fig. 5 | Radiation Oncology

Fig. 5

From: Modeling the effect of intratumoral heterogeneity of radiosensitivity on tumor response over the course of fractionated radiation therapy

Fig. 5

Comparison of treatment response of tumors characterized by different distribution widths in Eq. (3) and centered at same α and β parameters. a-b Pre- and post-treatment α and β distributions of different radiosensitivity heterogeneities (widths) compared to the pre-treatment distribution 4 (D4) in Fig. 4c (dashed ellipses) after a standard fractionation scheme of 70 Gy in 35 daily fractions at 2.0 Gy/day with weekend interruptions. Colormap represents the normalized densities of tumor cell subsets before and after treatment. The red arrows pointing from right to left represents the evolution of α and β from pre- to post-treatment values. c Tumor cell survival in response to fractionated radiotherapy. Shift in the mean values of (d) SF2 and (e) α/β ratio during treatment with respect to the pre-treatment values. f-g Intratumoral composition of radiosensitivity for different cell subsets in distribution 5 (D5) in (a) and distribution 6 (D6) in (b) before, during and after treatment. Pre-treatment parameters in Eq. (3) were σα = 4.5 × 10− 2 Gy− 1 (D5 in a) and σα = 8.5 × 10− 2 Gy− 1 (D6 in b) with σβ = 3.5 × 10− 3 Gy− 2, αc = 0.33 Gy− 1 and βc = 0.033 Gy− 2

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