Fig. 3
Variation of radiosensitivity during fractionated radiation therapy of a tumor as in Fig. 1. a Survival of tumor cell subsets characterized by different SF2 values in response to a standard fractionation scheme of 70 Gy in 35 daily fractions at 2.0 Gy/day with weekend interruptions. b Intratumoral composition of radiosensitivity for different tumor cell subsets before, during and after treatment. c-e Pre- and post-treatment α and β distributions after 15, 25 and 35 fractions. Colormap represents the normalized densities of tumor cell subsets before treatment and after 15, 25 and 35 fractions. The red arrows pointing from right to left represents the evolution of α and β from pre- to post-treatment values. f-g Variation on the mean values and standard deviations of α/β ratio and SF2 within the tumor during fractionated radiation therapy