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Fig. 1 | Radiation Oncology

Fig. 1

From: Modeling the effect of intratumoral heterogeneity of radiosensitivity on tumor response over the course of fractionated radiation therapy

Fig. 1

Model fitting of in vitro measurements in [30] of the change in the radiosensitivity of OE33 esophageal adenocarcinoma cell culture after exposure to fractionated radiation. a Representation of pre-treatment intratumoral distribution of α and β parameters. The sum of cell subset percentages is equal to 100%. b SF2 distribution with respect to α and β parameters. c Model fitting of tumor cell survival curves, and (d) the corresponding pre- and post-treatment α and β distributions. Colormap in (d) represents the normalized densities of each tumor cell subsets before and after treatment, where the red arrow pointing from right to left represents the evolution of α and β from pre- to post-treatment values. Pre-treatment parameters in Eq. (3) were αc = 0.40 Gy− 1, βc = 0.02 Gy− 2, σα = 6.5 × 10− 2 Gy− 1 and σβ = 3.5 × 10− 3 Gy− 2

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