Prognostic significance of lung radiation dose in patients with esophageal cancer treated with neoadjuvant chemoradiotherapy

Table 3 Univariate logistic regression of dosimetric factors and postoperative adverse events

	Pulmonary complications^a		Cardiac complications^b		30-day mortality		60-day mortality
Characteristics	OR (95% CI)	p-value	OR (95% CI)	p-value	OR (95% CI)	p-value	OR (95% CI)	p-value
Gross tumor volume	1.00 (0.99–1.01)	0.17	1.00 (0.99–1.00)	0.67	1.00 (0.98–1.02)	0.92	1.01 (1.00–1.02)	0.09
Target volume	1.00 (1.00–1.00)	0.20	1.00 (0.99–1.00)	0.39	1.00 (0.98–1.01)	0.24	1.00 (0.99–1.01)	0.92
Radiation dose	1.00 (1.00–1.00)	0.83	1.00 (1.00–1.00)	0.61	1.00 (1.00–1.00)	0.90	1.00 (1.00–1.00)	0.88
DVH of lung^c
V5	1.02 (1.00–1.04)	0.03	0.98 (0.95–1.02)	0.32	1.04 (0.97–1.12)	0.32	1.04 (0.98–1.11)	0.22
V20	0.99 (0.93–1.05)	0.72	0.94 (0.82–1.07)	0.35	1.00 (0.79–1.16)	0.65	0.99 (0.85–1.16)	0.91
Mean heart dose	1.00 (1.00–1.00)	0.82	0.99 (1.00–1.00)	0.13	1.00 (1.00–1.00)	0.71	1.00 (1.00–1.00)	0.31

Abbreviations: CI confidence interval, DVH dose-volume histogram, GTV gross tumor volume, OR odds ratio
^aAny grade
^bGrade ≥ 3 complications. The 7 patients had grade 3 cardiac dysrhythmia were analyzed
^cVx = volume (mL) of lung receiving X Gy or more

ISSN: 1748-717X