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Table 2 Adverse events during neoadjuvant chemoradiotherapy and after surgery

From: Prognostic significance of lung radiation dose in patients with esophageal cancer treated with neoadjuvant chemoradiotherapy

Event Any grade, n (%) Grade ≥ 3, n (%)
Postoperative events
 Pulmonary complicationsa 36 (27.6%) 15 (12.2)
 Cardiac complicationsc 21 (17.1%) 7 (5.7)
 Chylothorax 15 (12.2) 2 (1.6)
 Anastomotic leakage 21 (17.1) 9 (7.3)
Postoperative mortalityb
 7 days 0 (0)
 30 days 3 (2.4%)
 60 days 1 (0.8%)
Events during chemoradiotherapy
 Hematological toxicityd 113 (91.9) 54 (43.9)
 Weight loss 101 (82.1) 21 (17.1)
 Esophagitis 114 (92.7) 1 (0.8)
 Radiation pneumonitis 56 (45.5) 0 (0)
 Fatigue 77 (62.6) 0 (0)
  1. aPulmonary complications included pneumonia, serious atelectasis, pneumothorax, pleural effusion, pulmonary embolus, and acute respiratory failure
  2. bThe causes of postoperative mortality for the 4 patients were all postoperative complication of sepsis
  3. cCardiac complications included dysrhythmia, myocardial infarction, and left ventricular failure. All of 7 patients had grade 3 cardiac dysrhythmia; no patients had grade ≥ 4 cardiac complications
  4. dHematological toxicity included leukopenia, neutropenia, and thrombocytopenia