Prognostic significance of lung radiation dose in patients with esophageal cancer treated with neoadjuvant chemoradiotherapy

Table 2 Adverse events during neoadjuvant chemoradiotherapy and after surgery

Event	Any grade, n (%)	Grade ≥ 3, n (%)
Postoperative events
Pulmonary complications^a	36 (27.6%)	15 (12.2)
Cardiac complications^c	21 (17.1%)	7 (5.7)
Chylothorax	15 (12.2)	2 (1.6)
Anastomotic leakage	21 (17.1)	9 (7.3)
Postoperative mortality^b
7 days	0 (0)	–
30 days	3 (2.4%)	–
60 days	1 (0.8%)	–
Events during chemoradiotherapy
Hematological toxicity^d	113 (91.9)	54 (43.9)
Weight loss	101 (82.1)	21 (17.1)
Esophagitis	114 (92.7)	1 (0.8)
Radiation pneumonitis	56 (45.5)	0 (0)
Fatigue	77 (62.6)	0 (0)

^aPulmonary complications included pneumonia, serious atelectasis, pneumothorax, pleural effusion, pulmonary embolus, and acute respiratory failure
^bThe causes of postoperative mortality for the 4 patients were all postoperative complication of sepsis
^cCardiac complications included dysrhythmia, myocardial infarction, and left ventricular failure. All of 7 patients had grade 3 cardiac dysrhythmia; no patients had grade ≥ 4 cardiac complications
^dHematological toxicity included leukopenia, neutropenia, and thrombocytopenia

ISSN: 1748-717X