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Table 1 Overview of included trials. n.r. = not reported, FU = follow up, HR + = hormone receptor positive, N+/− = lymph node positive/negative, RN = regional nodes, IMN = internal mammary nodes, TV = target volume; ICS = intercostal space; BCS = breast conserving surgery; MTx = Mastectomy; AND = axillary node dissection

From: Which target volume should be considered when irradiating the regional nodes in breast cancer? Results of a network-meta-analysis

Trial

Synonym

Years trial

N total

med. Age

FU (y)

Post meno- pausal

HR+

CTx

N+

N-

T1

T2

Lateral Location

Surgery

Dose Breast

Dose RN

RT Boost

IMN TV

Main trial group

Hennequin 2013

French

1991–1997

1407

n.r.

8.6

n.r.

52%

61%

75%

25%

33%

52%

36%

MTx 100 AND 100%

50Gy

18 × 2.5 Gy =45Gy

none

ICS 1–5

N0

med/ central

or N+

Thorsen 2016

DBCG- IMN

2003–2007

3377

56

8.9

60%

80%

53%

100%

0%

41%

52%

60%

BCS 35% MTx 65 AND 100%

24x2Gy =48Gy

24x2Gy =48Gy

13%

ICS 1–4

N+

Poortmans 2015/2018

EORTC 22922

1996–2004

4004

54

15.7

59%

78%

55%

56%

45%

60%

36%

n.r.

BCS 76,1% MTx 23,9%

AND 100%

25x2Gy =50Gy

25x2Gy =50Gy

85%

ICS 1–3 (−4)

N0

med/ central

or N+

Whelan 2015

Ma.20

2000–2007

1832

54

9.5

nr

75%

91%

90%

10%

52%

46%

62%

BCS 100 AND 96% SNB 4%

25x2Gy =50Gy

25 × 1.8–2 Gy =45-50Gy

33%

ICS 1–3

N0 (high risk)

or N+