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Table 1 Overview of included trials. n.r. = not reported, FU = follow up, HR + = hormone receptor positive, N+/− = lymph node positive/negative, RN = regional nodes, IMN = internal mammary nodes, TV = target volume; ICS = intercostal space; BCS = breast conserving surgery; MTx = Mastectomy; AND = axillary node dissection

From: Which target volume should be considered when irradiating the regional nodes in breast cancer? Results of a network-meta-analysis

Trial Synonym Years trial N total med. Age FU (y) Post meno- pausal HR+ CTx N+ N- T1 T2 Lateral Location Surgery Dose Breast Dose RN RT Boost IMN TV Main trial group
Hennequin 2013 French 1991–1997 1407 n.r. 8.6 n.r. 52% 61% 75% 25% 33% 52% 36% MTx 100 AND 100% 50Gy 18 × 2.5 Gy =45Gy none ICS 1–5 N0
med/ central
or N+
Thorsen 2016 DBCG- IMN 2003–2007 3377 56 8.9 60% 80% 53% 100% 0% 41% 52% 60% BCS 35% MTx 65 AND 100% 24x2Gy =48Gy 24x2Gy =48Gy 13% ICS 1–4 N+
Poortmans 2015/2018 EORTC 22922 1996–2004 4004 54 15.7 59% 78% 55% 56% 45% 60% 36% n.r. BCS 76,1% MTx 23,9%
AND 100%
25x2Gy =50Gy 25x2Gy =50Gy 85% ICS 1–3 (−4) N0
med/ central
or N+
Whelan 2015 Ma.20 2000–2007 1832 54 9.5 nr 75% 91% 90% 10% 52% 46% 62% BCS 100 AND 96% SNB 4% 25x2Gy =50Gy 25 × 1.8–2 Gy =45-50Gy 33% ICS 1–3 N0 (high risk)
or N+