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Table 1 Summary Rationale For Neoadjuvant Chemo-RT Versus Adjuvant Chemo For Pancreatic Adenocarcinoma

From: Radiation therapy for pancreatic adenocarcinoma, a treatment option that must be considered in the management of a devastating malignancy

Comparator Variable

Neoadjuvant Chemo-RT

Up-front Surgery + Adjuvant Chemo

Citations to Support

Rate of Positive Margins

2–20%

16–60%

[16,17,18,19]

Incidence of Node Positivity

17–40%

62–80%

[13, 16, 17, 20]

Successful Treatment completion

70–80%

50–60%

[17, 21, 22]

Rates of Local Recurrence

5–15%

19–53%

[13, 17, 18, 23]