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Table 4 Multivariate Cox regression analysis

From: Neoadjuvant versus definitive chemoradiation in patients with squamous cell carcinoma of the esophagus

Parameter OS HR [95% CI] p-value PFS HR [95% CI] p-value LR HR [95% CI] p-value
Treatment Regimen (nCRT + S vs. dCRT) 1.453 [0.688; 3.070] 0.327 1.135 [0.592; 2.175] 0.704 0.434 [0.136; 1.382] 0.158
Age (continuous) 1.064 [1.019; 1.110] 0.005 1.054 [1.016; 1.093] 0.005 1.041 [0.984; 1.101] 0.165
Sex (female vs. male) 0.634 [0.316; 1.273] 0.200 0.696 [0.370; 1.311] 0.263 0.763 [0.277; 2.100] 0.601
Tumor lengths, cm (continuous) 1.044 [0.933; 1.168] 0.451 1.033 [0.932; 1.145] 0.541 1.057 [0.912; 1.224] 0.462
Tumor location (continuous) 0.939 [0.884; 0.998] 0.043 0.925 [0.876; 0.976] 0.005 0.843 [0.760; 0.935] 0.001
T-stage (Tis/T1/2 vs. T3/4) 1.434 [0.639; 3.221] 0.383 1.118 [0.527; 2.369] 0.772 1.997 [0.665; 5.993] 0.217
N-stage (N0 vs N1) 1.556 [0.558; 4.337] 0.398 0.821 [0.302; 2.234] 0.699 0.605 [0.135; 2.702] 0.510
Grading (G1/2 vs. G3) 2.674 [1.299; 4.503] 0.008 2.034 [1.098; 3.768] 0.024 2.322 [0.835; 6.453] 0.106
  1. IQR inter-quartiles-range, OS overall survival, PFS progression-free survival, LR local recurrence, HR Hazard ratio, CI Confidence interval