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Fig. 2 | Radiation Oncology

Fig. 2

From: Development and characterisation of acquired radioresistant breast cancer cell lines

Fig. 2

Radioresistant cell lines have modified basal proliferation rates relative to their parental cells. a SRB assays showing differences in proliferation rates between parental and RR cell lines grown in 2D cultures (2-way ANOVA with Holm-Sidak’s multiple comparisons test). b IHC of MTS stained for ki67 using MCF-7 and ZR-751 parental and RR cell lines with quantitative analysis of the % of positively stained cells (unpaired, two tailed t-test) (data expressed as mean ± SEM, n = 3, ****p ≤ 0.0001; ***p ≤ 0.001; *p ≤ 0.05). c Heatmap showing log2 mean-centered gene expression profiles of proliferation genes in parental and RR cell lines taken from the KEGG database cell cycle pathway; red = higher expression, green = lower expression. Heatmap clustering was carried out using Pearson correlation with average linkage

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