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Table 5 Anal canal Dmean results

From: A systematic review of dose-volume predictors and constraints for late bowel toxicity following pelvic radiotherapy

Study No of pts OAR Endpoint Dmean (in EQD2) constraint Risk of endpoint below this constraint Risk of endpoint above this constraint
Al-albany [18] 65 Anal sphincter region Incontinence >2X/week 43.2 8% 52%
Alsadius [19] 403 Anal canal Incontinence > 1x/month 40 5.2% 21%
Buettner [20] 388 Anal sphincter region Incontinence: moderate/severe (gr2) 47, though <30Gy ideal 5% (approx; read from graph)  
Smeenk [22] 36 Anal canal wall Urgency present 41.8 15% 62%
Peeters [21] 641 Anal canal wall Incontinence requiring pad >2x/week No constraint specified 16% at 19Gy 31% at 52Gy