Study | No of pts | OAR | Endpoint | Dmean (in EQD2) constraint | Risk of endpoint below this constraint | Risk of endpoint above this constraint |
---|---|---|---|---|---|---|
Al-albany [18] | 65 | Anal sphincter region | Incontinence >2X/week | 43.2 | 8% | 52% |
Alsadius [19] | 403 | Anal canal | Incontinence > 1x/month | 40 | 5.2% | 21% |
Buettner [20] | 388 | Anal sphincter region | Incontinence: moderate/severe (gr2) | 47, though <30Gy ideal | 5% (approx; read from graph) | Â |
Smeenk [22] | 36 | Anal canal wall | Urgency present | 41.8 | 15% | 62% |
Peeters [21] | 641 | Anal canal wall | Incontinence requiring pad >2x/week | No constraint specified | 16% at 19Gy | 31% at 52Gy |