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Table 5 Anal canal Dmean results

From: A systematic review of dose-volume predictors and constraints for late bowel toxicity following pelvic radiotherapy

Study

No of pts

OAR

Endpoint

Dmean (in EQD2) constraint

Risk of endpoint below this constraint

Risk of endpoint above this constraint

Al-albany [18]

65

Anal sphincter region

Incontinence >2X/week

43.2

8%

52%

Alsadius [19]

403

Anal canal

Incontinence > 1x/month

40

5.2%

21%

Buettner [20]

388

Anal sphincter region

Incontinence: moderate/severe (gr2)

47, though <30Gy ideal

5% (approx; read from graph)

 

Smeenk [22]

36

Anal canal wall

Urgency present

41.8

15%

62%

Peeters [21]

641

Anal canal wall

Incontinence requiring pad >2x/week

No constraint specified

16% at 19Gy

31% at 52Gy