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Table 3 Patient-, tumor-and treatment-related factors compared to local and locoregional recurrences

From: Salivary gland carcinoma (SGC) with perineural spread and/or positive resection margin – high locoregional control rates after photon (chemo) radiotherapy - experience from a monocentric analysis

Univariate  
  Local recurrence
p-value
Hazard ratio
(95% confidence interval)
Locoregional recurrence
p-value
Hazard ratio
(95% confidence interval)
Patient-dependent
 Gender 0.389 0.050
  female vs. male 0.38 (0.04–3.69) 0.16 (0.02–1.31)
 Age at diagnosis 0.839 0.828
  ≥70y vs. <70y 1.27 (0.13–12.24) 0.79 (0.09–6.68)
Tumor-related  
 Primary tumor site 0.368 0.664
  non-parotid vs. parotid 0.37 (0.04–3.54) 0.72 (0.16–3.23)
 Histologic Subtype 0.541 0.953
  non-adenoidcystic vs. 2.00 0.956
  adenoid cystic (0.21–19.21) (0.21–4.29)
 T classification 0.773 0.196
  T3/4 vs. T1/2 1.39 (0.15–13.43) 3.75 (0.44–31.85)
 Primary tumor size, cm 0.703 0.711
  >3 cm vs. ≤ 3 cm 0.63 (0.06–6.95) 1.35 (0.27–6.72)
 N classification 0.075 0.227
  N1/2 vs. N0 53.2 (0.02–180,704.08) 2.68 (0.51–14.09)
 Number of metastatic lymph nodes 0.285 0.224
  >1 vs. ≤ 1 3.42 (0.31–37.85) 2.68 (0.52–13.88)
 Histological tumor grade 0.747 0.537
  High vs. low/intermediate 1.20 (0.39–3.75) 1.30 (0.56–2.99)
 Extranodal extension 0.228 0.581
  yes vs. no 0.03 (0.00–656.48) 0.55 (0.06–4.78)
 Perineural Spread 0.222 0.403
  yes vs. no 0.27 (0.03–2.60) 0.41 (0.05–3.51)
Lymphovascular invasion 0.163 0.587
yes vs. no 4.72 (0.43–52.22) 1.64 (0.27–9.82)
 Vascular invasion 0.380 0.680
  yes vs. no 2.80 (0.25–31.05) 1.58 (0.18–14.23)
 Bone invasion 0.222 0.603
  yes vs. no 3.72 (0.39–36.03) 1.75 (0.21–14.60)
Treatment-related  
 Resection margin 0.119 0.179
  R1/2 vs. R0 5.04 (0.52–48.53) 2.81 (0.62–12.72)
 Resection margin 0.002 0.031
  R2 vs R0/1 11.26 (1.58–80.45) 5.15 (0.98–26.93)
 Second primary tumor resection 0.293 0.543
  yes vs. no 0.034 (0.00–910.95) 0.52 (0.06–4.37)
 Neck Dissection 0.598 0.852
  yes vs. no 0.55 (0.06–5.28) 1.22 (0.15–10.18)
 Number of dissected nodes 0.675 0.708
  ≥10 vs. < 10 0.60 (0.05–6.64) 1.50 (0.18–12.88)
 Lymph node density (%) 0.110 0.246
  >4 vs. ≤4 56.27 (0.01–637,456.03) 2.71 (0.48–15.42)
 Radiation dose 0.333 0.698
  ≥64Gy vs. <64Gy 0.34 (0.04–3.31) 0.66 (0.08–5.50)
 Planning target Volume 0.318 0.108
  primary tumor region & 28.57 (0.00–1,127,372.02) 34.53 (0.03–47,010.85)
  regional lymph drainage vs.
  primary tumor region
 Radiation technique 0.099 0.226
  IMRT vs. 3D 0.02 (0.00–82.02) 0.290 (0.03–2.45)