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Table 4 Doses to OARs

From: Dosimetric evaluation of four whole brain radiation therapy approaches with hippocampus and inner ear avoidance and simultaneous integrated boost for limited brain metastases

 

sIMRT

dIMRT

VMAT

Tomo

p value

Hippocampus Dmax (Gy)

14.3 ± 1.1

14.5 ± 1.4

15.8 ± 0.7

15.5 ± 0.9

b,c,d,e

Hippocampus Dmean (Gy)

9.7 ± 0.2

10.1 ± 0.3

10.0 ± 0.6

10.0 ± 0.7

> 0.05

Hippocampus Dmin (Gy)

8.9 ± 0.3

9.3 ± 0.2

8.3 ± 0.4

7.6 ± 0.7

a,b,c,d,e,f

Left inner ear Dmean (Gy)

13.7 ± 0.7

13.8 ± 0.8

13.4 ± 1.0

13.1 ± 1.0

> 0.05

Right inner ear Dmean (Gy)

13.6 ± 0.8

13.8 ± 0.7

13.7 ± 1.6

13.3 ± 1.1

> 0.05

Eyes Dmax (Gy)

32.5 ± 4.9

32.9 ± 4.8

26.7 ± 6.1

30.8 ± 4.7

b,d,f

Lens Dmax (Gy)

5.7 ± 0.6

5.8 ± 0.6

6.8 ± 1.3

5.5 ± 0.5

b,d,f

Optic nerves Dmax (Gy)

33.6 ± 1.7

33.8 ± 1.7

32.0 ± 2.0

31.3 ± 0.9

c,e

Brainstem Dmax (Gy)

35.4 ± 1.1

35.7 ± 0.9

35.9 ± 0.6

34.0 ± 0.2

c,e,f

  1. Each value was calculated from the data of all 10 patients. Values are expressed as mean ± SD. sIMRT step-and-shoot intenseity-modulated radiotherapy, dIMRT dynamic-intensity modulated radiation therapy, VMAT volumetric-modulated arc therapy, Tomo helical tomotherapy. a: sIMRT vs dIMRT, b: sIMRT vs VMAT, c: sIMRT vs Tomo, d: dIMRT vs VMAT, e: dIMRT vs Tomo, f: VMAT vs Tomo. If c is in the “p value” column, it means that there is statistical significance between sIMRT and Tomo