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Table 4 Doses to OARs

From: Dosimetric evaluation of four whole brain radiation therapy approaches with hippocampus and inner ear avoidance and simultaneous integrated boost for limited brain metastases

  sIMRT dIMRT VMAT Tomo p value
Hippocampus Dmax (Gy) 14.3 ± 1.1 14.5 ± 1.4 15.8 ± 0.7 15.5 ± 0.9 b,c,d,e
Hippocampus Dmean (Gy) 9.7 ± 0.2 10.1 ± 0.3 10.0 ± 0.6 10.0 ± 0.7 > 0.05
Hippocampus Dmin (Gy) 8.9 ± 0.3 9.3 ± 0.2 8.3 ± 0.4 7.6 ± 0.7 a,b,c,d,e,f
Left inner ear Dmean (Gy) 13.7 ± 0.7 13.8 ± 0.8 13.4 ± 1.0 13.1 ± 1.0 > 0.05
Right inner ear Dmean (Gy) 13.6 ± 0.8 13.8 ± 0.7 13.7 ± 1.6 13.3 ± 1.1 > 0.05
Eyes Dmax (Gy) 32.5 ± 4.9 32.9 ± 4.8 26.7 ± 6.1 30.8 ± 4.7 b,d,f
Lens Dmax (Gy) 5.7 ± 0.6 5.8 ± 0.6 6.8 ± 1.3 5.5 ± 0.5 b,d,f
Optic nerves Dmax (Gy) 33.6 ± 1.7 33.8 ± 1.7 32.0 ± 2.0 31.3 ± 0.9 c,e
Brainstem Dmax (Gy) 35.4 ± 1.1 35.7 ± 0.9 35.9 ± 0.6 34.0 ± 0.2 c,e,f
  1. Each value was calculated from the data of all 10 patients. Values are expressed as mean ± SD. sIMRT step-and-shoot intenseity-modulated radiotherapy, dIMRT dynamic-intensity modulated radiation therapy, VMAT volumetric-modulated arc therapy, Tomo helical tomotherapy. a: sIMRT vs dIMRT, b: sIMRT vs VMAT, c: sIMRT vs Tomo, d: dIMRT vs VMAT, e: dIMRT vs Tomo, f: VMAT vs Tomo. If c is in the “p value” column, it means that there is statistical significance between sIMRT and Tomo