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Table 3 Schematic diagram for the schedule of enrolment, interventions, and assessments

From: Comparisons of different neoadjuvant chemotherapy regimens with or without stereotactic body radiation therapy for borderline resectable pancreatic cancer: study protocol of a prospective, randomized phase II trial (BRPCNCC-1)

Time point Enrolment Allocation Post-allocation
During chemotherapy with or without SBRT Post-surgery
1 month 2 months 3 months 4 months 1 month 3 months 6 months 1 year 2 years
Enrolment
 Eligibility screen X           
 Informed consent X           
 Allocation   X          
Interventions
 Gem+nab-paclitaxel   
 Gem+nab-paclitaxel+SBRT   
 S-1 + nab-paclitaxel+SBRT   
Assessments
 Physical examinations X   X X X X X X X X X
 Laboratory tests X   X X X X X X X X X
 Imaging examinations X    X   X   X X X X
 cfDNA, CTC a X      Xb      
 Organoid X       X     
 DNA sequencing of specimens X       X     
 Adverse effects    X X X X X X    
 Surgical safety        X X    
 Survival status           X X
  1. aConducted if recurrence occurs besides those performed in the above time points
  2. bConducted after completion of neoadjuvant therapy and before surgery