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Table 3 Schematic diagram for the schedule of enrolment, interventions, and assessments

From: Comparisons of different neoadjuvant chemotherapy regimens with or without stereotactic body radiation therapy for borderline resectable pancreatic cancer: study protocol of a prospective, randomized phase II trial (BRPCNCC-1)

Time point

Enrolment

Allocation

Post-allocation

During chemotherapy with or without SBRT

Post-surgery

1 month

2 months

3 months

4 months

1 month

3 months

6 months

1 year

2 years

Enrolment

 Eligibility screen

X

          

 Informed consent

X

          

 Allocation

 

X

         

Interventions

 Gem+nab-paclitaxel

  

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 Gem+nab-paclitaxel+SBRT

  

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 S-1 + nab-paclitaxel+SBRT

  

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Assessments

 Physical examinations

X

 

X

X

X

X

X

X

X

X

X

 Laboratory tests

X

 

X

X

X

X

X

X

X

X

X

 Imaging examinations

X

  

X

 

X

 

X

X

X

X

 cfDNA, CTC a

X

    

Xb

     

 Organoid

X

     

X

    

 DNA sequencing of specimens

X

     

X

    

 Adverse effects

  

X

X

X

X

X

X

   

 Surgical safety

      

X

X

   

 Survival status

         

X

X

  1. aConducted if recurrence occurs besides those performed in the above time points
  2. bConducted after completion of neoadjuvant therapy and before surgery