Table 1 Patient characteristics
Characteristics | All patients | RT to cavity only | RT to cavity and in situ BM | p-value |
|---|---|---|---|---|
Gender | Â | Â | Â | 0.855 |
 Male | 32 (43) | 26 (35) | 6 (8) |  |
 Female | 43 (57) | 39 (52) | 4 (5) |  |
Age at diagnosis (years) | 62.9 (33.3–79.2) | 63.3 (33.3–79.2) | 58.2 (42.2–76.1) | 0.436 |
Histology | Â | Â | Â | 0.262 |
 Lung | 37 (49) | 35 (47) | 2 (3) |  |
 Breast | 6 (8) | 5 (7) | 1 (1) |  |
 Melanoma | 13 (17) | 11 (15) | 2 (3) |  |
 RCC | 2 (3) | 2 (3) | 0 (0) |  |
 Colorectal | 8 (11) | 6 (8) | 2 (3) |  |
 Other | 9 (12) | 6 (8) | 3 (4) |  |
Location of cavity | Â | Â | Â | 0.441 |
 Supratentorial | 61 (79) | 54 (70) | 7 (9) |  |
 Infratentorial | 16 (21) | 14 (18) | 2 (3) |  |
Number of BM |  |  |  | < 0.001 |
 1 | 63 (84) | 63 (84) | NA |  |
 2 | 11 (15) | 2 (3) | 9 (12) |  |
 3 | 1 (1) | 0 (0) | 1 (1) |  |
Fractionation | Â | Â | Â | 0.517 |
 SRS | 60 (78) | 53 (69) | 7 (9) |  |
 HFSRT | 17 (22) | 14 (18) | 3 (4) |  |
ECOG score | Â | Â | Â | 0.305 |
 0 | 54 (72) | 48 (64) | 6 (8) |  |
 1 | 14 (19) | 12 (16) | 2 (3) |  |
 2 or NA | 7 (9) | 5 (6) | 2 (3) |  |
GPA score | Â | Â | Â | 0.002 |
 3.5–4 | 23 (31) | 23 (31) | 0 (0) |  |
 2.5–3 | 35 (47) | 32 (43) | 3 (4) |  |
 0–2 | 13 (17) | 8 (11) | 5 (7) |  |
 NA | 4 (5) | 2 (3) | 2 (3) |  |
BM symptomatic initially | Â | Â | Â | 0.490 |
 No or unknown | 5 (7) | 4 (5) | 1 (1) |  |
 Yes | 70 (93) | 61 (81) | 9 (12) |  |
Residual tumor | Â | Â | Â | 0.143 |
 No | 60 (78) | 54 (70) | 6 (8) |  |
 Yes | 17 (22) | 13 (17) | 4 (5) |  |
Systemic cancer treatment | Â | Â | Â | 0.363 |
 No or unknown | 37 (49) | 32 (43) | 5 (7) |  |
 Yes | 38 (51) | 33 (44) | 5 (7) |  |
  Cytotoxic | 25 (33) | 22 (29) | 3 (4) |  |
  Immunotherapy/targeted | 6 (8) | 4 (5) | 2 (3) |  |
  Combined | 7 (9) | 7 (9) | 0 (0) |  |
Extracranial tumor status | Â | Â | Â | 0.462 |
 Stable | 27 (36) | 25 (33) | 2 (3) |  |
 Progression | 44 (59) | 37 (49) | 7 (9) |  |
 Unknown | 4 (5) | 3 (4) | 1 (1) |  |
Initial BMV | 0.55 (0.05–11.4) | 0.59 (0.05–11.4) | 0.48 (0.13–4.93) | 0.705 |
BMV | 0.13 (0–84.4) | 0 (0–64.9) | 3.97 (1.34–84.4) | 0.067 |
MRI follow-up at 3 months |  |  |  | 0.112 |
 No | 35 (47) | 28 (37) | 7 (9) |  |
 Yes | 40 (53) | 37 (49) | 3 (4) |  |
No. of MRI per 180 days | 1 (0–5.2) | 1.1 (0–5.2) | 0.3 (0–3.8) | 0.083 |