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Table 1 The delineation of CTV for tumor in different location

From: A phase I/II radiation dose escalation trial using simultaneous integrated boost technique with elective nodal irradiation and concurrent chemotherapy for unresectable esophageal Cancer

Location Upper margin Lower margin Lymph node stations included in CTV
Upper thoracic esophagus (Ut) Cricothyroid membrane / 1–1 .5cm superior to the highest metastatic lymph node 3 cm inferior to the lower margin of the tumor / 1–1 .5cm inferior to the lowest metastatic lymph node supraclavicular, station 1R, 1 L, 2R, 2 L, 4R, 4 L, 7 (station 3, 8, paracardial and left gastric lymph nodes may be included if metastatic lymph nodes exist)
Middle thoracic esophagus (Mt) First thoracic vertebra / 1–1 .5cm superior to the highest metastatic lymph node 3 cm inferior to the lower margin of the tumor / 1–1 .5cm inferior to the lowest metastatic lymph node supraclavicular, station 1R, 1 L, 2R, 2 L, 4R, 4 L, 7, 8 (station 3, paracardial and left gastric lymph nodes may be included if metastatic lymph nodes exist)
Lower thoracic esophagus (Lt) 3-5 cm superior to the tumor / 1–1 .5cm superior to the highest metastatic lymph node 3 cm inferior to the lower margin of the tumor / 1–1 .5cm inferior to the lowest metastatic lymph node station 2R, 2 L, 4R, 4 L, 7, 8, paracardial and left gastric lymph nodes (supraclavicular, staion1R, 1 L, 3 may be included if metastatic lymph nodes exist)