Prognostic value of subventricular zone involvement in relation to tumor volumes defined by fused MRI and O-(2-[18F]fluoroethyl)-L-tyrosine (FET) PET imaging in glioblastoma multiforme

Table 3 Analysis of patient survival and imaging parameters in relation to SVZ involvement (Mann-Whitney test)

Parameter	SVZ involved			SVZ not involved			p-values
Parameter	Mean	Median	Range	Mean	Median	Range	p-values
PFS	11.7	5.0	3–47	9.1	7.5	2–37	0.650
OS	14.1	10.0	4–48	18.8	15.0	9–41	0.021
Age	56.1	58.0	34–73	50.8	48.0	29–72	0.207
PET_VOL10	49.7	51.1	3.07–115.63	27.0	25.7	1.24–67.93	0.007
PET_VOL60	46.0	50.2	0.79–101.7	21.9	19.4	1.48–60.06	0.007
PET VOL DIFF	4.5	4.5	−16.06 - 27,61	5.2	4.4	−3.28 - 20.5	0.832
T1-Gad	38.6	33.5	11.2–89.31	21.5	16.3	4.23–53.48	0.024
PET T1-Gad	64.2	62.5	17.8–131.5	35.9	29.9	5.1–103.1	0.004
PET-T1Gad w/o tumor bed	59,4	58,6	11.2–129.2	29.7	26.2	2.8: - 86.6	0.001
TBR_MEANDIFF	0.2	0.2	−0.07 - 0.69	0.3	0.2	−0.09 - 0.8	0.634
TBR_MAXDIFF	0.3	0.2	−0.43 - 2.33	1.0	0.6	−0.4 - 5.45	0.067
SUV_MEANDIFF	−0.1	−0.1	−1.14 - 1.01	0.0	−0.1	− 0.49 - 1.25	0.807
SUV_MAXDIFF	0.6	0.0	−0.84 - 4.28	0.5	0.6	−1.5 - 3.5	0.832
SUV_MAX10	3.7	3.3	1.03–10.16	3.1	3.4	1.26–4.79	0.646
SUV_MEAN10	1.8	1.7	0.8–2.7	1.5	1.5	0.98–2.04	0.025
TBR_MAX10	3.1	2.9	1.92–7.66	3.3	3.0	1.37–6.38	0.734
TBR_MEAN10	2.5	2.3	2–3.95	2.4	2.3	1.85–3.92	0.518
SUV_MAX60	3.8	3.4	1.48–8.21	3.0	3.0	1.78–5.36	0.103
SUV_MEAN60	1.9	1.9	1.18–3.23	1.7	1.7	0.96–2.76	0.207
TBR_MAX60	2.8	2.5	1.88–5.33	2.3	2.2	0.93–3.2	0.067
TBR_MEAN60	2.3	2.2	1.89–3.39	2.1	2.0	1.65–3.12	0.079

ISSN: 1748-717X