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Table 4 Overview of acute and chronic toxicity (n = 70)

From: Salvage radiotherapy for recurrent hypopharyngeal and laryngeal squamous cell carcinoma (SCC) after first-line treatment with surgery alone: a 10-year single-centre experience

characteristic acute toxicity (n = 70) chronic toxicity (n = 63)
No. (%) No. (%)
under RT and 6 weeks post RT 3–6 months post RT 12 months post RT 24 months post RT at last follow-up
toxicity
 grade 1 10 (14) 19 (27) 22 (31) 23 (33) 17 (24)
 grade 2 39 (56) 21 (30) 10 (14) 6 (9) 5 (7)
 grade 3 14 (20) 4 (6) 3 (4) 3 (4) 3 (4)
 grade 4 0 4 (6) 1 (1) 1 (1)  
dysphagia
 grade 1 6 (9) 7 (10) 6 (9) 6 (9) 5 (7)
 grade 2 28 (40) 4 (6) 5 (7) 1 (1) 0
 grade 3 4 (6) 3 (4) 3 (4) 3 (4) 3 (4)
odynophagia
 grade 1 8 (11) 1 (1) 0 0 0
 grade 2 14 (20) 0 0 0 0
 grade 3 5 (7) 0 0 0 0
mucositits
 grade 1 12 (17) 1 (1) 0 0 0
 grade 2 36 (51) 0 0 0 0
 grade 3 2 (3) 0 0 0 0
dermatitis
 grade 1 19 (27) 2 (3) 0 0 0
 grade 2 18 (26) 1 (1) 0 0 0
 grade 3 4 (6) 0 0 0 0
xerostomia
 grade 1 32 (46) 30 (43) 17 (24) 13 (19) 10 (14)
 grade 2 12 17 () 4 (6) 2 (3) 2 (3) 2 (3)
 grade 3 1 (1) 0 0 0 0
hoarseness
 grade 1 16 (23) 15 (21) 13 (19) 12 (17) 10 (14)
 grade 2 13 (19) 7 (10) 3 (4) 1 (1) 2 (3)
 grade 3 3 (4) 1 (1) 1 (1) 1 (1) 0
fatigue
 grade 1 6 (9) 3 (4) 2 (3) 1 (1) 1 (1)
 grade 2 6 (9) 2 (3) 1 (1) 0 0
dysgeusia
 grade 1 11 (16) 14 (20) 11 (16) 8 (11) 7 (10)
 grade 2 20 (29) 4 (6) 0 0 0
dry cough
 grade 1 7 (10) 5 (7) 2 (3) 2 (3) 0
 grade 2 1 (1) 0 0 0 0
lymphedema
 grade 1 6 (9) 12 (17) 2 (3) 1 (1) 1 (1)
 grade 2 8 (11) 2 (3) 1 (1) 1 (1) 4 (6)
 grade 3 1 (1) 1 (1) 1 (1) 1 (1) 1 (1)
 grade 4a 0 3 (4) 0 0 0
fistula
 laryngoesophageal 0 1 (1) 0 0 0
 laryngocutaneous 0 0 1 (1) 0 0
wound healing disorder 0 0 0 1 (1) 0
gastric tube dependence 24 (34) 9 (13) 5 (7) 1 (1) 1 (1)
  1. abbreviations: RT radiotherapy
  2. awith tracheotomy for acute dyspnea