Table 4 Overview of acute and chronic toxicity (n = 70)
characteristic | acute toxicity (n = 70) | chronic toxicity (n = 63) | |||
|---|---|---|---|---|---|
No. (%) | No. (%) | ||||
under RT and 6 weeks post RT | 3–6 months post RT | 12 months post RT | 24 months post RT | at last follow-up | |
toxicity | |||||
 grade 1 | 10 (14) | 19 (27) | 22 (31) | 23 (33) | 17 (24) |
 grade 2 | 39 (56) | 21 (30) | 10 (14) | 6 (9) | 5 (7) |
 grade 3 | 14 (20) | 4 (6) | 3 (4) | 3 (4) | 3 (4) |
 grade 4 | 0 | 4 (6) | 1 (1) | 1 (1) |  |
dysphagia | |||||
 grade 1 | 6 (9) | 7 (10) | 6 (9) | 6 (9) | 5 (7) |
 grade 2 | 28 (40) | 4 (6) | 5 (7) | 1 (1) | 0 |
 grade 3 | 4 (6) | 3 (4) | 3 (4) | 3 (4) | 3 (4) |
odynophagia | |||||
 grade 1 | 8 (11) | 1 (1) | 0 | 0 | 0 |
 grade 2 | 14 (20) | 0 | 0 | 0 | 0 |
 grade 3 | 5 (7) | 0 | 0 | 0 | 0 |
mucositits | |||||
 grade 1 | 12 (17) | 1 (1) | 0 | 0 | 0 |
 grade 2 | 36 (51) | 0 | 0 | 0 | 0 |
 grade 3 | 2 (3) | 0 | 0 | 0 | 0 |
dermatitis | |||||
 grade 1 | 19 (27) | 2 (3) | 0 | 0 | 0 |
 grade 2 | 18 (26) | 1 (1) | 0 | 0 | 0 |
 grade 3 | 4 (6) | 0 | 0 | 0 | 0 |
xerostomia | |||||
 grade 1 | 32 (46) | 30 (43) | 17 (24) | 13 (19) | 10 (14) |
 grade 2 | 12 17 () | 4 (6) | 2 (3) | 2 (3) | 2 (3) |
 grade 3 | 1 (1) | 0 | 0 | 0 | 0 |
hoarseness | |||||
 grade 1 | 16 (23) | 15 (21) | 13 (19) | 12 (17) | 10 (14) |
 grade 2 | 13 (19) | 7 (10) | 3 (4) | 1 (1) | 2 (3) |
 grade 3 | 3 (4) | 1 (1) | 1 (1) | 1 (1) | 0 |
fatigue | |||||
 grade 1 | 6 (9) | 3 (4) | 2 (3) | 1 (1) | 1 (1) |
 grade 2 | 6 (9) | 2 (3) | 1 (1) | 0 | 0 |
dysgeusia | |||||
 grade 1 | 11 (16) | 14 (20) | 11 (16) | 8 (11) | 7 (10) |
 grade 2 | 20 (29) | 4 (6) | 0 | 0 | 0 |
dry cough | |||||
 grade 1 | 7 (10) | 5 (7) | 2 (3) | 2 (3) | 0 |
 grade 2 | 1 (1) | 0 | 0 | 0 | 0 |
lymphedema | |||||
 grade 1 | 6 (9) | 12 (17) | 2 (3) | 1 (1) | 1 (1) |
 grade 2 | 8 (11) | 2 (3) | 1 (1) | 1 (1) | 4 (6) |
 grade 3 | 1 (1) | 1 (1) | 1 (1) | 1 (1) | 1 (1) |
 grade 4a | 0 | 3 (4) | 0 | 0 | 0 |
fistula | |||||
 laryngoesophageal | 0 | 1 (1) | 0 | 0 | 0 |
 laryngocutaneous | 0 | 0 | 1 (1) | 0 | 0 |
wound healing disorder | 0 | 0 | 0 | 1 (1) | 0 |
gastric tube dependence | 24 (34) | 9 (13) | 5 (7) | 1 (1) | 1 (1) |