Is mean heart dose a relevant surrogate parameter of left ventricle and coronary arteries exposure during breast cancer radiotherapy: a dosimetric evaluation based on individually-determined radiation dose (BACCARAT study)

Table 3 Association parameters between mean dose to the left ventricle and coronary arteries and the mean heart dose

	LV	LAD	LCX	LMCA	RCA
Left-sided BC patients
Ratio Dmean struc/MHD (mean ± SD)	2.1 ± 0.6	5.6 ± 2.2	0.7 ± 0.4	0.5 ± 0.2	0.3 ± 0.1
Correlation with MHD (r, p-value)	0.78, < 0.0001	0.67, < 0.0001	0.33, 0.017	0.47, < 0.0001	0.60, < 0.0001
Right-sided BC patients
Ratio Dmean struc/MHD (mean ± SD)	0.2 ± 0.1	0.2 ± 0.1	0.3 ± 0.1	0.8 ± 0.2	2.7 ± 0.7
Correlation with MHD (r, p-value)	0.55, 0.03	0.71, 0.0026	0.64, 0.01	0.81, 0.0002	0.60, 0.02

LV Left Ventricle, LAD Left Anterior Descending Artery, LCX Left Circumflex Artery, LMCA Left Main Coronary Artery, RCA Right Coronary Artery, BC breast cancer, SD standard deviation, MHD Mean heart dose, Dmean struc mean dose absorbed by the delineated substructure

ISSN: 1748-717X