Skip to main content

Advertisement

Table 2 Predictors of locoregional recurrence and distant metastasis identified using a Cox proportional hazards model

From: Prognostic values of mid-radiotherapy 18F-FDG PET/CT in patients with esophageal cancer

  Locoregional recurrence Distant metastasis
Univariate analysis Univariate analysis
HR 95% CI p value HR 95% CI p value
Patient factor
 ECOG PS (0–1 vs. 2) 4.21 0.44–39.93 0.21 0.47 0.11–1.93 0.29
Stage
 I – IIIA vs. IIIB, IIIC 49.49 0.01–180,664.89 0.35 0.67 0.15–2.94 0.59
PET1
 SUVmax 0.96 0.81–1.13 0.62 0.95 0.84–1.07 0.37
 SUVmean 0.89 0.63–1.25 0.49 0.85 0.66–1.09 0.21
 MTVa 1.00 0.96–1.05 0.84 1.00 0.96–1.03 0.85
 TLGa 1.00 1.00–1.00 0.93 1.00 1.00–1.00 0.59
 GTVa 1.00 0.97–1.03 0.84 1.01 0.99–1.03 0.42
PET2
 SUVmax 1.24 0.95–1.63 0.12 1.08 0.90–1.29 0.42
 SUVmean 1.92 0.80–4.62 0.15 1.54 0.90–2.65 0.12
 MTVa 1.02 0.96–1.09 0.48 1.01 0.95–1.06 0.80
 TLGa 1.01 1.00–1.02 0.29 1.00 0.99–1.01 0.75
 GTVa 0.99 0.94–1.04 0.64 1.02 0.99–1.05 0.17
Relative difference
 ΔSUVmax 0.98 0.95–1.00 0.09 0.97 0.94–0.99 0.01
 ΔSUVmean 0.98 0.95–1.01 0.18 0.95 0.91–0.98 0.00
 ΔMTV 0.97 0.95–0.99 0.01 1.00 0.98–1.02 0.76
 ΔTLG 0.98 0.96–0.99 0.01 0.98 0.96–1.00 0.04
 ΔGTV 1.01 0.97–1.05 0.67 1.00 0.97–1.03 0.82
  Locoregional recurrence Distant metastasis
Multivariate analysis Multivariate analysis
HR 95% CI p value HR 95% CI p value
Relative difference
 ΔSUVmax 0.98 0.94–1.02 0.32 1.04 0.98–1.11 0.22
 ΔSUVmean     0.90 0.82–0.99 0.02
 ΔMTV 0.98 0.96–1.00 0.03    
 ΔTLG 1.24 0.80–1.56 0.12 1.00 0.98–1.02 0.75
  1. The foreparts of the parentheses were set as the reference groups
  2. Abbreviations: ECOG PS Eastern Cooperative Oncology Group performance status, SUVmax maximum standardized uptake value, SUVmean mean standardized uptake value, MTV metabolic tumor volume, TLG total lesion glycolysis, HR hazard ratio, CI confidence interval
  3. aLog transformed