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Table 1 Patient and treatment characteristics for patients with unresectable bulky tumors treated with SBRT partial tumor irradiation targeting the hypoxic tumor segment (SBRT-PATHY)

From: Novel stereotactic body radiation therapy (SBRT)-based partial tumor irradiation targeting hypoxic segment of bulky tumors (SBRT-PATHY): improvement of the radiotherapy outcome by exploiting the bystander and abscopal effects

Characteristic No. (%)
Sex
 Male 17 (74)
 Female 6 (26)
 Median age at SBRT-PATHY 74 years, range: 41–86
Primary tumor site
 Lung 16 (69.6)
 Kidney 3 (13.1)
 Skin 2 (8.7)
 Prostate 1 (4.3)
 Unknown 1 (4.3)
Histology
 Adenocarcinoma 5 (21.7)
 Squamous 13 (56.6)
 Melanoma 1 (4.3)
 Renal cell carcinoma 3 (13.1)
 Unknown 1 (4.3)
Treated site
 Lymph node metastases: Neck levels IIA right and IV left Retroperitoneal Mediastinum 5 (21.7)
 Lung primary: Central: ULL, LLL, URL, Mediastinum Peripheral: LRL, URL, ULL, LLL 14 (60.9)
 Lung metastases: Peripheral: LRL, ULL 3 (13.1)
 Adrenal gland (left) 1 (4.3)
 Oligo-metastatic patients: 14 (60.9)
 1 metastasis 3 (21.4)
 > 1 ≤ 3 metastases 8 (57.1)
 > 3 ≤ 5 metastases 3 (21.4)
 Metastatic site(s) Lung, Neck, Mediastinum, Soft Tissue, Retroperitoneal, Adrenal, Bone, Liver
 Metastases in the same organ as treated bulky 2 (14.3)
 Metastases in the different organ(s) 7 (50)
 Both (in the same and in the different organs) 5 (35.7)
 Systemic therapy 7 (30.4)
 Chemotherapy 4 (17)
 Immunotherapy 2 (8.7)
 Hormonal (androgen deprivation therapy) 1 (4.3)
 GTV volume mean/range (cm3) 179.8/30–499
 GTV diameter mean/range (cm) 9.1/6–17
 BTV volume mean/range (cm3) 57.1/5–137
 SUVmax mean/range for GTV 23/7–85
 SUVmax mean/range for BTV 3/1–3
Prescription dose
 10Gy × 1 to 70% isodose-line 15 (65.2)
 12Gy × 1 to 70% isodose-line 4 (17.4)
 10Gy × 3 to 70% isodose-line 4 (17.4)
  1. Abbreviations: ULL-upper left lobe, LLL-lower left lobe, URL-upper right lobe, LRL-lower right lobe, GTV-gross tumor volume, BTV-bystander tumor volume, SBRT-PATHY-SBRT PArtial Tumor irradiation of the HYpoxic segment, SUV-standardized uptake values