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Fig. 1 | Radiation Oncology

Fig. 1

From: Novel stereotactic body radiation therapy (SBRT)-based partial tumor irradiation targeting hypoxic segment of bulky tumors (SBRT-PATHY): improvement of the radiotherapy outcome by exploiting the bystander and abscopal effects

Fig. 1

HYPOTHESIS; RADIATION-HYPOXIA-INDUCED BYSTANDER (BE) AND ABSCOPAL EFFECTS (AE): The hypoxic tumor cells showed higher “abscopal potential” than did the normoxic tumor cells, probably due to their higher survival following inductive radiation (10 Gy). In addition to the differential radio-sensitivity, the definitive BE/AE-intensity is determined by multiple factors, such as radiation dose, tumor biology, oxygen status, and balance between pro-angiogenic and anti-angiogenic “abscopal messengers.” The lower part of the figure shows the radiobiology of SBRT-PATHY: irradiation of hypoxic segment results in induction of radiation-hypoxia-induced BE and AE, leading to regression of partially irradiated tumor as well as unirradiated distant metastases

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