Table 5 Dose constraints in the SCOPE 2 trial

PTV_6000

(High dose arm only)

V95% (57Gy)

>  95%

≥ 90%

Dmedian

100% (60Gy)

The median should be between 98 and 102% of the prescription dose (i.e., 60Gy).

PTV_5000

V95% (47.5Gy)

>  95%

≥ 90%

Dmedian

100% (50Gy, standard dose arm only)

The median should be between 98 and 102% of the prescription dose (i.e., 50Gy, standard dose arm only).

External

D1.8 cc

< 107% of highest prescribed dose

SpinalCord_PRV

D0.1 cc

< 40Gy

<  42 Gy

Heart

Dmean

<  25Gy

<30Gy

V30Gy

<  45%

-

Lungs

Dmean

< 17Gy

<19Gy

(Combined lungs)

V20Gy

<  20

≤25

Stomach_excl_PTV_5000

(Stomach excluding PTV_5000)

V50Gy

<  16 cc

<  25 cc

Liver

Dmean

≤28Gy

≤30Gy

V30Gy

V30Gy < 30%

-

Kidney_L and Kidney_R

(Individual kidneys)

V20Gy

<  25%

≤30%