Table 4 Target volumes for SCOPE 2

GTVp

Includes:

 • Primary tumour (above or below GOJ)

 • Any involved nodes above the GOJ and ≤ 30 mm of the primary tumour volume

 • The circumference of the oesophagus at the level of disease

GTVn

Includes any involved nodes below GOJ or > 30 mm from primary tumour (GTVp).

It is not required to include the full circumference of the oesophagus.

GTVpn

Union of GTVp and GTVn, and the circumference of the intervening oesophagus/proximal stomach, to include only GTVn above the diaphragm.

CTVA

GTVpn extended along the axis of the oesophagus:

 • Sup-inf margin of 20 mm from the edges of GTVp or 10 mm from the highest/lowest involved lymph node (GTVn).

 • The whole circumference of the oesophageal wall should be included.

 • Inferiorly CTVA should not extend below the GOJ.

CTVn

GTVn + 5 mm isotropically

CTVB

CTVA + 10 mm circumferentially:

 • CTVB is edited to exclude lung, pericardium, large vessels, right and main bronchi, liver and the vertebrae, both above and below the diaphragm. DO NOT edit beyond CTVC. For T4 tumours, DO NOT edit the respective structure (e.g., if T4 right pleura, do not edit the CTVB extending into right lung).

 • Below the GOJ CTVB is grown manually to include the volume at risk to a total of 20 mm below GTVp and at least 10 mm below the lowest GTVn). This volume includes CTVn and the elective nodal regions at high risk of microscopic spread.

CTVC

CTVA+  5 mm circumferential margin.

ITV

(For distal tumours where 4DCT used)

Composite of CTV volumes (from reference 3D, max end-inhale and max end-exhale scans), grown to account for any additional motion seen from all other 4DCT phases.

PTV_5000

(Standard and high dose arm)

GTVp + 5 mm isotropically

GTVp_Ref + 5 mm isotropically