Extracranial Radiation (n = 13,586) | Intracranial Radiation (n = 8624) | ||||||
---|---|---|---|---|---|---|---|
Hazard Ratio | 95% Confidence Interval | p-value | Hazard Ratio | 95% Confidence Interval | p-value | ||
Sex | Male | 1.00 | Ref | < 0.0001 | 1.00 | Ref | < 0.0001 |
Female | 0.85 | 0.81–0.89 | 0.82 | 0.78–0.86 | |||
Age | 18–59 | 1.00 | Ref | 0.087 | 1.00 | Ref | < 0.0001 |
60–69 | 0.98 | 0.94–1.03 | 1.10 | 1.04–1.16 | |||
70–79 | 1.00 | 0.95–1.05 | 1.27 | 1.19–1.35 | |||
80+ | 1.10 | 1.01–1.20 | 1.43 | 1.24–1.64 | |||
Comorbidity | 0 | 1.00 | Ref | 0.002 | 1.00 | Ref | < 0.0001 |
1 | 1.04 | 0.99–1.08 | 1.09 | 1.03–1.15 | |||
> 2 | 1.12 | 1.05–1.20 | 1.25 | 1.15–1.36 | |||
Histology | Adenocarcinoma | 1.00 | Ref | < 0.0001 | 1.00 | Ref | < 0.0001 |
Non-adenocarcinoma | 1.09 | 1.05–1.14 | 1.18 | 1.13–1.25 | |||
Race | White | 1.00 | Ref | < 0.0001 | 1.00 | Ref | < 0.0001 |
Non-white | 0.88 | 0.83–0.92 | 0.86 | 0.80–0.92 | |||
Insurance | Uninsured | 1.00 | Ref | 0.753 | 1.00 | Ref | 0.533 |
Insured | 1.02 | 0.92–1.12 | 1.04 | 0.93–1.16 | |||
Facility Type | Academic | 1.00 | Ref | < 0.0001 | 1.00 | Ref | < 0.0001 |
Nonacademic | 1.11 | 1.07–1.16 | 1.21 | 1.15–1.27 | |||
Systemic Therapy | Chemotherapy | 1.00 | Ref | 0.002 | 1.00 | Ref | < 0.0001 |
Immunotherapy | 0.90 | 0.85–0.96 | 0.83 | 0.77–0.90 | |||
Radiation | EBRT | 1.00 | Ref | < 0.0001 | 1.00 | Ref | < 0.0001 |
SRT | 0.51 | 0.45–0.58 | 0.62 | 0.58–0.66 |