Preliminary result of definitive radiotherapy in patients with non-small cell lung cancer who have underlying idiopathic pulmonary fibrosis: comparison between X-ray and proton therapy

Table 1 Clinical characteristics according to treatment (N = 30)

Characteristics	X-ray (n = 22)	Proton (n = 8)	p value
Age [years; median (range)]	75 (55–84)	77 (62–85)	0.640
Sex
Female	0 (0%)	1 (12.5%)	0.092
Male	22 (100%)	7 (87.5%)
Smoking Status
Never smoker	0 (0%)	1 (12.5%)	0.092
Current or Ex-smoker	22 (100%)	7 (87.5%)
ECOG performance
0–1	13 (59.1%)	8 (100%)	0.031
2–3	9 (40.9%)	0 (0%)
Clinical Stage
IA-IB	15 (68.2%)	4 (50.0%)	0.361
IIA-IIB	7 (31.8%)	4 (50.0%)
Histology
Adenocarcinoma	5 (31.3%)	2 (28.6%)	0.775
Squamous cell carcinoma	10 (62.5%)	5 (71.4%)
Others	1 (6.2%)	0 (0%)
Not proven	6	1
Pulmonary function test
FEV₁
> 50%	21 (95.5%)	8 (100%)	0.540
≤ 50%	1 (4.5%)	0 (0%)
DLCO
> 60%	9 (40.9%)	2 (25.0%)	0.424
≤ 60%	13 (59.1%)	6 (75.0%)
DLCO
> 40%	20 (90.9%)	7 (87.5%)	0.783
≤ 40%	2 (9.1%)	1 (12.5%)
GAP index
1	9 (40.9%)	1 (12.5%)	0.144
2–3	13 (59.1%)	7 (87.5%)

ECOG Eastern Cooperative Oncology Group, FEV₁ forced expiratory volume in 1 s; DLCO, diffusing capacity of the lung for carbon monoxide

ISSN: 1748-717X