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Table 3 Calculated doses to organs at risk for HITS, HEARTS, low-dose HEARTS, and SIB-HEARTS and clinical application of SIB-HEARTS to leukemia cutis with various OARs for the head, chest and abdomen

From: Simultaneous integrated boost with helical arc radiotherapy of total skin (HEARTS) to treat cutaneous manifestations of advanced, therapy-refractory cutaneous lymphoma and leukemia - dosimetry comparison of different regimens and clinical application

Organs at risk Original planning Revised planning AML with leukemia cutis
HITS
(30 Gy)
HEARTS
(30 Gy)
Low-dose
HEARTS
(12 Gy)
SIB-
HEARTS
(25/12 Gy)
SIB-
HEARTS
(21/15 Gy)
Mean dose or maximal dose (Gy)
Whole brain 8.0 6.8 2.9 2.0 2.1
Brain stem (max.) 2.5 3.2 1.3 1.4 1.6
Spinal cord (max.) 3.8 3.8 1.5 1.8 3.5
Right lens (max.) 2.1 29.7 13.1 12.2 8.7
Left lens (max.) 2.2 30.6 12.9 12.7 7.8
Right eye 3.8 21.8 9.2 9.0 3.8
Left eye 4.1 21.6 9.3 9.4 4.1
Right parotid gland 29.3 10.4 9.3 6.8 9.0
Left parotid gland 29.9 20.2 8.8 12.2 12.2
Lips 15.8 33.1 13.1 12.4 17.0
Oral cavity 8.7 8.2 3.3 2.4 2.7
Pharynx 5.2 4.5 1.8 1.6 4.0
Larynx 23.2 17.2 7.4 6.1 21.9
Trachea 13.7 10.4 4.4 4.8 5.0
Thyroid 24.7 20.2 8.6 11.4 12.9
Esophagus-upper part 8.1 4.6 2.0 2.4 7.8
Esophagus-middle part 3.1 2.6 1.0 1.1 1.8
Esophagus-lower part 2.9 2.6 1.0 1.0 1.6
Right lung 4.7 3.4 1.5 1.6 2.5
Left lung 4.5 3.4 1.5 1.5 2.8
Whole lung 4.6 3.7 1.5 1.5 2.6
Heart 3.3 2.9 1.1 1.2 1.8
Liver 5.2 3.9 1.6 1.9 2.5
Spleen 6.8 5.2 2.2 2.0 3.3
Right kidney 3.9 3.3 1.3 1.5 2.2
Left kidney 4.3 3.5 1.4 1.4 2.5
Bladder 11.2 4.7 1.9 1.7 2.1
Rectum 8.5 5.5 2.2 2.1 2.5
Uterus&ovary 4.3 3.2 1.3 1.3
Cervix&vagina 15.7 9.3 3.8 3.7
Intestine 4.7 3.5 1.4 1.5 2.1
Stomach 3.6 3.0 1.2 1.3 1.7
Bone marrow in different parts
 Cervical spine 5.8 3.6 1.5 1.9 2.2
 Thoracic spine 6.3 3.6 1.4 1.5 2.3
 Lumbar spine 4.0 3.3 1.3 1.3 1.9
 Sacrum 4.8 4.0 1.6 1.4 3.0
 Right iliac crest 8.9 6.1 2.4 2.1 3.6
 Left iliac crest 8.5 6.2 2.5 4.0 3.1
 Right femur 12.3 3.5 1.5 1.6 2.2
 Left femur 10.3 3.4 1.4 1.5 2.9
 Right pelvic bone 13.1 5.7 2.3 2.2 3.0
 Left pelvic bone 12.2 5.8 2.3 3.6 2.8