Early stage non-small cell lung cancer treated with pencil beam scanning particle therapy: retrospective analysis of early results on safety and efficacy

Table 2 Characteristics of treatments

	Number of Patients
Breath control techniques
Gating	20
Active breathing control	7
Free Breathing	4
Prescriptions
5–7.5 GyE X 8–10 Fx	12
4–5 GyE X 15–16 Fx	3
2.25–3.5 GyE X 22–31 Fx	16
BED₁₀ (GyE), median (range)	96 (75–119)
Radiation techniques/sources
PRT only	6
PRT + CIRT boost	6
CIRT only	19^a
Chemotherapy	6
1 cycle (neoadjuvant of pemetrexed+ cisplatin)	1
3 cycles (concurrent of Taxol+ cisplatin)	1
4 cycles (neoadjuvant of etoposide+ cisplatin)	1
4 cycles (neoadjuvant of pemetrexed X 3+ docetaxel X 1)	1
5 cycles (neoadjuvant of gemcitabine+ cisplatin X 3 + concurrent of Taxol+ cisplatin X 2)	1
6 cycles (neoadjuvant of gemcitabine+ cisplatin)	1

Abbreviations:BED₁₀ Biological effective dose (α/β = 10), PRT Proton radiation therapy, CIRT Carbon ion radiotherapy
^aIncluded one patient discontinued X-ray based Intensity Modulated Radiation Therapy (IMRT) after 2 fractions due to pneumonia, and received CIRT for 69 GyE/23 fractions