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Table 4 Univariate Analysis of Variables Correlated with Various Clinical Endpoints

From: Grading of MRI–detected skull-base invasion in nasopharyngeal carcinoma with skull-base invasion after intensity-modulated radiotherapy

Characteristic 5y-LFFS P 5y-DMFS P 5y-PFS P 5y-OS P
Sex
 Male 89.7 0.052 84.9 0.359 73.7 0.017 86.2 0.301
 Female 95.2   88.6   82.7   90.1  
Age (y)
  ≥ 48 89.6 0.245 85.9 0.866 75.0 0.646 83.3 0.037
 <48 93.2   86.3   78.0   91.5  
Skull-base invasion
 LSBI 92.6 0.296 90.0 0.116 81.3 0.032 93.1 0.024
 ESBI 90.8   84.2   73.6   84.0  
T classification
 T3 93.1 0.093 88.5 0.036 79.9 0.042 90.9 0.014
 T4 89.5   83.2   72.6   83.2  
N classification
 N0 92.2 0.909 94.1 < 0.001 84.7 0.066 87.7 0.879
 N1 90.7   89.3   79.2   89.9  
 N2 91.5   84.3   73.6   86.3  
 N3 93.7   69.9   66.4   80.8  
Overall Stage (the 8th AJCC)
 III 92.7 0.220 91.1 0.001 81.8 0.008 92.4 0.003
 IVa 90.4   81.5   71.9   82.7  
Concurrent chemotherapy
 Yes 91.3 0.585 86.4 0.471 75.8 0.924 87.7 0.706
 No 94.1   80.9   76.7   84.7  
  1. ESBI extensive skull-base invasion, LSBI limited skull-base invasion, LFFS local failure free survival, DMFS distant metastasis free survival, PFS progression free survival, OS overall survival