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Table 3 Patterns of Treatment Failure for Patients with Skull-base Invasion after IMRT

From: Grading of MRI–detected skull-base invasion in nasopharyngeal carcinoma with skull-base invasion after intensity-modulated radiotherapy

Treatment Failure Pattern

LSBI group (N = 185)

ESBI group (N = 284)

P

Distant only

12 (6.5)

34 (12.0)

0.051

 Bone

3 (1.6)

9 (3.2)

 

 Liver

3 (1.6)

9 (3.2)

 

 Lung

5 (2.7)

11 (3.9)

 

 Bone and liver

0

1 (0.4)

 

 Bone and lung

1 (0.5)

2 (0.7)

 

 Lung and liver

0

1 (0.4)

 

 Other

0

1a(0.4)

 

Regional and distant

4 (2.2)

4 (1.4)

 

Local and distant

2 (1.1)

3 (1.1)

 

Local, regional, and distant

0

1 (0.4)

 

Local only

6 (3.2)

18 (6.3)

 

Regional only

6 (3.2)

12 (4.2)

 

Local and regional

3 (1.6)

2 (0.7)

 

Total

33 (17.8)

74 (26.1)

0.038

  1. ESBI extensive skull-base invasion, LSBI limited skull-base invasion
  2. a Lung, liver, mediastinal and retroperitoneal lymph nodes, and left adrenal gland