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Table 3 Patterns of Treatment Failure for Patients with Skull-base Invasion after IMRT

From: Grading of MRI–detected skull-base invasion in nasopharyngeal carcinoma with skull-base invasion after intensity-modulated radiotherapy

Treatment Failure Pattern LSBI group (N = 185) ESBI group (N = 284) P
Distant only 12 (6.5) 34 (12.0) 0.051
 Bone 3 (1.6) 9 (3.2)  
 Liver 3 (1.6) 9 (3.2)  
 Lung 5 (2.7) 11 (3.9)  
 Bone and liver 0 1 (0.4)  
 Bone and lung 1 (0.5) 2 (0.7)  
 Lung and liver 0 1 (0.4)  
 Other 0 1a(0.4)  
Regional and distant 4 (2.2) 4 (1.4)  
Local and distant 2 (1.1) 3 (1.1)  
Local, regional, and distant 0 1 (0.4)  
Local only 6 (3.2) 18 (6.3)  
Regional only 6 (3.2) 12 (4.2)  
Local and regional 3 (1.6) 2 (0.7)  
Total 33 (17.8) 74 (26.1) 0.038
  1. ESBI extensive skull-base invasion, LSBI limited skull-base invasion
  2. a Lung, liver, mediastinal and retroperitoneal lymph nodes, and left adrenal gland