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Table 1 Characteristics of the 668 included patients

From: The prolonged interval between induction chemotherapy and radiotherapy is associated with poor prognosis in patients with nasopharyngeal carcinoma

Characteristics

Interval ≤ 30 days (608 patients)

Interval > 30 days (60 patients)

P-value

Age (years)

44.5 ± 11.0

44.8 ± 11.2

0.808a

Gender

  

0.304b

 Male

462 (76.0%)

42 (70.0%)

 

 Female

146 (24.0%)

18 (30.0%)

 

CCI score

  

0.088c

 0

519 (85.4%)

56 (93.3%)

 

 1

87 (14.3%)

4 (6.7%)

 

  ≥ 2

2 (0.3%)

0 (0%)

 

T categorye

  

0.034c

 T1

54 (8.9%)

3 (5.0%)

 

 T2

86 (14.1%)

6 (10.0%)

 

 T3

299 (49.2%)

27 (45.0%)

 

 T4

169 (27.8%)

24 (40.0%)

 

N categorye

  

0.211c

 N0

47 (7.7%)

5 (8.3%)

 

 N1

339 (55.8%)

29 (48.3%)

 

 N2

101 (16.6%)

7 (11.7%)

 

 N3

121 (19.9%)

19 (31.7%)

 

Stagee

  

0.105c

 II

77 (12.7%)

7 (11.7%)

 

 III

263 (43.3%)

19 (31.7%)

 

 IVa

268 (44.1%)

34 (56.7%)

 

EBV DNA (103 copies/ml)

5.6 (0–3290)

6.1 (0–3660)

0.476c

lnDNAf

7.5 ± 4.0

7.8 ± 4.1

0.504a

WHO pathology

  

0.728d

 I

6 (1.0%)

0 (0%)

 

 II

28 (4.6%)

4 (6.7%)

 

 III

574 (94.4%)

56 (93.3%)

 

IC cycles

  

<  0.001c

 1

75 (12.3%)

5 (8.3%)

 

 2

315 (51.8%)

21 (35.0%)

 

 3

187 (30.8%)

18 (30.0%)

 

 ≥ 4

31 (5.1%)

16 (26.7%)

 

Concurrent chemotherapy

  

0.028b

 Yes

497 (81.7%)

42 (70.0%)

 

 No

111 (18.3%)

18 (30.0%)

 
  1. Data presented as number (%), mean ± standard deviation or median (range)
  2. Abbreviations: CCI Charlson comorbidity index, EBV Epstein-Barr virus, IC Induction chemotherapy
  3. aIndependent samples t-test
  4. bPearson chi-square test
  5. cWilcoxon rank-sum test
  6. dFisher’s exact test
  7. eAccording to the 8th edition of AJCC/UICC staging system
  8. flnDNA = ln (EBV DNA × 1000 + 1)