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Table 1 Five hypofractionated schedules and equivalent dose in 2-Gy

From: Long-term results of a phase II study of hypofractionated proton therapy for prostate cancer: moderate versus extreme hypofractionation

      

EQD2

  

Daily dose (CGE)

Number of fractions

fractions / week

Treatment time (Days)

Prostate cancer (α/β = 1.5 Gy)

Acute toxicity (α/β = 10 Gy)

Late toxicity (α/β = 3 Gy)

Reference dose in 2 Gy/fraction

2

36

5

49

72.0

72.0

72.0

MHF

Arm 1

3

20

4

(Mon. Tue, Thu, Fri)

32

77.1

69.6

72.0

Arm 2

3.6

15

3

(Mon, Wed, Fri)

32

78.7

63.8

71.3

Arm 3

4.7

10

2

(Tue, Thu)

30

83.3

58.2

72.4

EHF

Arm 4

7

5

2

(Tue, Thu)

14

85.0

55.5

70.0

Arm 5

7

5

1

(Wed)

28

85.0

46.3

70.0

  1. EQD2 equivalent dose in 2-Gy fractions (see Supplementary Appendix of reference 6), CGE cobalt gray equivalent = proton dose in Gy × 1.1, MHF moderate hypofractionation, EHF extreme hypofractionation