Skip to main content

Table 2 Overview of local control and toxicity in prospective trials using intensity modulated radiotherapy (IMRT)

From: Neoadjuvant image-guided helical intensity modulated radiotherapy of extremity sarcomas – a single center experience

Study Year Patients RT-margins LPFS Toxicity (≥ II)
Alektiar et al. 2007 neo: 7
adj: 24
a: 2 cm
l: 5 cm
2y 95% Dermatitis: 26%
Edema: 13%
Joint stiffness: 19%
Neuropathy: 5%
Wound Complication: 9.6%
Fractures: 6.4%
Alektiar et al. 2008 neo: 7
adj: 34
a: 2 cm
l: 3 cm
5y 95% Edema: 12.2%
Joint sitffness: 17.1%
Wound complication: 9.9%
chronic:
Dermatitis: 1.9%
Fractures: 4.8%
O’Sullivan et al. 2013 neo: 59 a: 1.5 cm
l: 4 cm
5y 88% Wound complications: 30.4%
chronic:
Edema: 11.1%
Joint stiffness: 5.6%
Fractures: 0%
Folkert et al. 2014 adj: 165 a: 1–1.5 cm
l: 3–4 cm
5y 93% Dermatitis: 31.5%
Edema: 8%
Joint stiffness: 14.5%
chronic:
Joint stiffness: 12.5%
Fracture: 7.9%
Wang et al. 2015 neo: 42a high grade:
a:1.5, l: 3 cm
low grade:
a:1 cm, l: 2 cm
2y 89% chronic:
Edema, joint stiffness or fibrosis: 11.9%
  1. label: a axial, adj adjuvant, neo neoadjuvant, LPFS Local progression free survival, l longitudinal, RT radiotherapy, y year
  2. apartially combined with chemotherapy