Table 3 Multivariate analysis of factors affecting survival and further brain control after recurrence in the brain after therapeutic or prophylactic irradiation
Characteristics | Survival after Brain Failure | Brain Control after Brain Failure | ||
|---|---|---|---|---|
Hazard Ratio (95% CI) | P Value | Hazard Ratio (95% CI) | P Value | |
ECOG performance status score at brain recurrence | ||||
0–2 | 1.00 | 0.006 | 1.00 | 0.103 |
≥3 | 3.039 (1.374–6.721) | 1.955 (0.874–4.372) | ||
≥4 chemo cycles before brain recurrence | ||||
No | 1.00 | 0.045 | – | – |
Yes | 0.351 (0.126–0.975) | – | ||
No. of brain lesions at brain recurrence | ||||
≤4 | 1.00 | 0.116 | 1.00 | 0.142 |
> 4 | 1.534 (0.900–2.615) | 1.572 (0.859–2.875) | ||
Symptom from brain metastases at brain recurrence | ||||
No | 1.00 | 0.376 | 1.00 | 0.499 |
Yes | 1.310 (0.721–2.380) | 1.233 (0.672–2.260) | ||
Extracranial disease at brain recurrence | ||||
Controlled | 1.00 | < 0.001 | 1.00 | 0.055 |
Uncontrolled | 3.059 (1.665–5.622) | 1.855 (0.987–3.600) | ||
Chemotherapy after brain recurrence | ||||
No | 1.00 | < 0.001 | 1.00 | 0.01 |
Yes | 0.174 (0.094–0.324) | 0.457 (0.250–0.832) | ||
WBI or G-knife for brain recurrence | ||||
No | 1.00 | 0.001 | 1.00 | 0.050 |
Yes | 0.367 (0.205–0.656) | 0.533 (0.283–1.001) | ||
Time from first brain irradiation to brain recurrence, mo | ||||
< 6 | 1.00 | 0.153 | – | – |
≥6 | 0.679 (0.400–1.154) | – | ||