Table 1 Patient characteristics by treatment received for brain recurrence
All Patients (n = 85) | Group 1 (SRS) (n = 33)a | Group 2 (WBI) (n = 14)b | Group 3 (Chemo only) (n = 16) | Group 4 (Observation) (n = 22) | |
|---|---|---|---|---|---|
Age at brain recurrence, years | |||||
< 63 | 42 | 16 | 6 | 10 | 10 |
≥63 | 43 | 17 | 8 | 6 | 12 |
ECOG performance status score at brain recurrence | |||||
0–2 | 75 | 32 | 11 | 15 | 17 |
≥3 | 10 | 1 | 3 | 1 | 5 |
Sex | |||||
Male | 33 | 12 | 6 | 6 | 9 |
Female | 52 | 21 | 8 | 10 | 13 |
Ethnicity | |||||
White | 69 | 23 | 11 | 15 | 20 |
Non-white | 16 | 10 | 3 | 1 | 2 |
Initial disease stage | |||||
Limited | 24 | 12 | 3 | 2 | 7 |
Extensive | 61 | 21 | 11 | 14 | 15 |
Brain metastases at initial diagnosis | |||||
No | 52 | 23 | 7 | 8 | 14 |
Yes | 33 | 10 | 7 | 8 | 8 |
No. of brain lesions at initial diagnosis | |||||
≤4 | 72 | 30 | 10 | 13 | 19 |
> 4 | 13 | 3 | 4 | 3 | 3 |
Intent of first brain irradiation | |||||
Prophylactic | 33 | 14 | 5 | 6 | 8 |
Therapeutic | 52 | 19 | 9 | 10 | 14 |
≥4 chemo cycles before brain recurrence | |||||
No | 5 | 1 | 1 | 1 | 4 |
Yes | 80 | 32 | 13 | 15 | 18 |
Thoracic radiation therapy dose, Gy | |||||
< 45 | 28 | 6 | 7 | 7 | 8 |
≥45 | 57 | 27 | 7 | 9 | 14 |
No. of brain lesions at brain recurrence | |||||
≤4 | 46 | 27 | 5 | 5 | 9 |
> 4 | 39 | 6 | 9 | 11 | 13 |
Symptoms from brain lesions at brain recurrence | |||||
No | 49 | 25 | 2 | 10 | 12 |
Yes | 36 | 8 | 12 | 6 | 10 |
Extracranial disease at brain recurrence | |||||
Controlled | 29 | 15 | 5 | 5 | 4 |
Uncontrolled | 56 | 18 | 9 | 11 | 18 |
Chemotherapy after brain recurrence | |||||
No | 55 | 20 | 13 | 0 | 22 |
Yes | 30 | 13 | 1 | 16 | 0 |
Time from the end of first brain irradiation to brain recurrence, mo | |||||
< 6 | 44 | 13 | 7 | 8 | 16 |
≥ 6 | 41 | 20 | 7 | 8 | 6 |