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Table 2 Difference of dosimetric factors among three lung definition methods

From: Excluding PTV from lung volume may better predict radiation pneumonitis for intensity modulated radiation therapy in lung cancer patients

Factors Mean Difference 95% CI P Value*
V5 (%) Lung-PTV vs. Lung-PGTV 2.2 2.0–2.4 < 0.001
Lung-PTV vs. Total Lung 2.7 2.5–3.0 < 0.001
Lung-PGTV vs. Total Lung 0.6 0.4–0.7 < 0.001
V20 (%) Lung-PTV vs. Lung-PGTV 3.5 3.3–3.8 < 0.001
Lung-PTV vs. Total Lung 4.5 4.2–4.8 < 0.001
Lung-PGTV vs. Total Lung 1.0 0.8–1.1 < 0.001
MLD (Gy) Lung-PTV vs. Lung-PGTV 1.7 1.6–1.8 < 0.001
Lung-PTV vs. Total Lung 2.3 2.1–2.4 < 0.001
Lung-PGTV vs. Total Lung 0.6 0.5–0.7 < 0.001
  1. Abbreviation: PTV planning target volume, PGTV planning gross tumor volume, V5/20 volume of lung receiving a dose ≥5/20 Gy, MLD mean lung dose
  2. *By repeated analysis of variance test (ANOVA)