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Table 3 Clinical courses of patients with esophageal fistula newly developed after treatment

From: Clinical outcomes of radiation therapy for clinical T4b oesophageal cancer with airway invasion

No.

Age/Sex

PS

Treatment

Time to fistula formation

Site

Management

Diet at last f/u

Survival (month)

Status

1

60/M

1

Definitive CCRT, 62Gy/34Fx

6 months

TEF

Feeding- jejunostomy

Tube feeding

8

DOD (aspiration pneumonia)

2

65/M

1

Definitive RT alone, 54Gy/18Fx

1 month

TEF

PEG

Tube feeding

2

DOD (aspiration pneumonia)

3

68/M

1

Neoadjuvant CCRT, 45Gy/25Fx

15 months

TEF

None

None

15

DOD (aspiration pneumonia, bleeding)

4

68/M

2

Palliative RT, 30Gy/10Fx

1 month

BEF

PEG

Tube feeding

3

DOD (aspiration pneumonia)

5

54/M

1

Palliative RT, 30Gy/12Fx

3 months

BEF

PEG

Tube feeding

4

DOD (aspiration pneumonia)

6

74/M

2

Definitive RT alone, 60Gy/20Fx

3 months

TMF

PRG

Tube feeding

4

DOD (disease progression)

7

65/M

2

Palliative RT, 30Gy/10Fx

3 months

TEF

Feeding- jejunostomy

Tube feeding

7

DOD (aspiration pneumonia)

8

63/M

1

Neoadjuvant CCRT, 44Gy/22Fx

1 month

BEF

Feeding- jejunostomy

Oral intake

29

Alive with no evidence of diseasea

9

61/M

3

Palliative RT, 30Gy/10Fx

1 month

TEF

PEG

Tube feeding

4

DOD (aspiration pneumonia)

10

48/M

1

Palliative RT, 39Gy/13Fx

After ICT

TEF

PEG

Tube feeding

6

DOD (aspiration pneumonia)

11

70/M

2

Palliative RT, 39Gy/13Fx

After ICT

BEF

PEG

Tube feeding

4

DOD (aspiration pneumonia)

12

56/M

1

Definitive CCRT, 66Gy/33Fx

8 months

TEF

PRG

Tube feeding

12

Alive with no evidence of disease

13

59/M

1

Definitive CCRT, 66Gy/33Fx

5 months

TEF

PRG

Tube feeding

11

Alive with disease

  1. Abbreviation: PS performance status, RT radiotherapy, CCRT Concurrent chemoradiotherapy, BEF bronchoesophageal fistula, TEF tracheoesophageal fistula, PEG percutaneous endoscopic gastrostomy, PRG percutaneous radiological gastrostomy, DOD dead of disease
  2. aBEF was newly developed at 1 month’ follow-up after completion of RT. Later, closing of fistula was found at 2 months’ follow-up and he performed operation and still alive with no evidence of disease