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Table 2 Univariate and multivariate Cox regression analyses of OS and ICC

From: Locally dose-escalated radiotherapy may improve intracranial local control and overall survival among patients with glioblastoma

 

Univariate Analysis

Multivariate Analysis

HR (range)

P-value

HR (range)

P-value

OS

 Age

1.020 (1.001–1.039)

0.034

1.015 (0.996–1.035)

0.121

 Dose escalation

0.472 (0.259–0.858)

0.014

0.494 (0.269–0.906)

0.023

 Localization

1.064 (0.924–1.225)

0.387

  

 Resection status

1.338 (1.009–1.772)

0.043

1.369 (1.035–1.811)

0.028

 No Temozolomide

1.421 (0.624–3.232)

0.403

  

 RPA Class

1.183 (0.982–1.424)

0.077

  

 PTV (ml)

1.000 (0.999–1.001)

0.542

  

ICC

 Age

1.007 (0.991–1.023)

0.423

  

 Dose escalation

0.512 (0.302–0.866)

0.013

0.498 (0.294–0.844)

0.010

 Localization

1.124 (0.976–1.295)

0.105

  

 Resection status

1.344 (1.032–1.750)

0.028

1.365 (1.047–1.780)

0.021

 No Temozolomide

1.857 (0.866–3.983)

0.112

  

 RPA

1.062 (0.891–1.267)

0.502

  

 PTV (ml)

1.000 (1.000–1.001)

0.304

  
  1. OS overall survival, ICC intracranial control, HR hazard ratio, RPA recursive partitioning analysis; resection status was classified as gross total resection, partial resection or biopsy
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Radiation Oncology

ISSN: 1748-717X

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