Table 3 Univariable and multivariable Cox regression analysis: Characteristics associated with overall survival for patients who had brain imaging at diagnosis and at least stable disease after first line chemotherapy
Characteristic | Univariable analysis | Multivariable analysis | ||||
|---|---|---|---|---|---|---|
HR | 95% CI | P value | HR | 95% CI | P value | |
Sociodemographic and clinical characteristics | ||||||
Age at diagnosis, years | ||||||
≥ 70 (vs < 70) | 1.08 | 0.59–1.97 | 0.812 | 1.33 | 0.66–2.70 | 0.428 |
Gender | ||||||
Male (vs Female) | 0.20 | 0.07–0.57 | 0.003 | |||
ECOG PS | ||||||
2–4 (vs 1) | 2.39 | 1.17–4.87 | 0.017 | 2.80 | 1.08–7.23 | 0.034 |
Smoking statusa | ||||||
Smoker (vs Lifetime non-smoker) | 1.35 | 0.72–2.54 | 0.343 | |||
Charlson’s co-morbidity index | ||||||
1–2 (vs 0) | 1.49 | 0.77–2.88 | 0.241 | |||
≥ 3 (vs 0) | 2.79 | 0.88–8.85 | 0.082 | |||
Chemotherapy treatment characteristics | ||||||
No. of cycles of first line chemotherapy | ||||||
4–6 (vs 1–3) | 0.37 | 0.17–0.79 | 0.011 | 0.31 | 0.12–0.83 | 0.020 |
Received Platinum based first line chemotherapy | 0.27 | 0.08–0.93 | 0.038 | |||
Received second line chemotherapy | 0.48 | 0.25–0.92 | 0.027 | |||
Received more than two lines of chemotherapy | 0.38 | 0.13–1.11 | 0.076 | |||
Radiotherapy treatment characteristics | ||||||
Received prophylactic cranial irradiation | 0.37 | 0.17–0.77 | 0.008 | 0.11 | 0.04–0.32 | < 0.001 |
Received thoracic radiation | 0.55 | 0.30–1.03 | 0.063 | 0.47 | 0.22–0.98 | 0.045 |
Received whole brain radiation | 0.77 | 0.42–1.41 | 0.395 | 0.18 | 0.08–0.43 | < 0.001 |
Received skeletal radiation | 2.06 | 0.88–4.85 | 0.097 | 0.50 | 0.16–1.62 | 0.248 |