Table 2 Univariable and multivariable Cox regression analysis: Characteristics associated with overall survival for patients who had at least stable disease after first line chemotherapy
Characteristic | Univariable analysis | Multivariable analysis | ||||
|---|---|---|---|---|---|---|
HR | 95% CI | P value | HR | 95% CI | P value | |
Sociodemographic and clinical characteristics | ||||||
Age at diagnosis, years | ||||||
≥ 70 (vs < 70) | 1.17 | 0.73–1.88 | 0.506 | 1.02 | 0.60–1.73 | 0.952 |
Gender | ||||||
Male (vs Female) | 0.47 | 0.22–1.01 | 0.053 | |||
ECOG PS | ||||||
2–4 (vs 1) | 1.76 | 0.98–3.14 | 0.057 | 2.53 | 1.12–5.70 | 0.025 |
Smoking status | ||||||
Ex-smoker (vs Lifetime non-smoker) | 3.37 | 0.78–14.46 | 0.103 | |||
Smoker (vs Lifetime non-smoker) | 2.07 | 0.50–8.62 | 0.316 | |||
Charlson’s co-morbidity index | ||||||
1–2 (vs 0) | 1.24 | 0.75–2.06 | 0.400 | |||
≥ 3 (vs 0) | 2.24 | 0.77–6.54 | 0.139 | |||
Had brain imaging at diagnosis | 1.28 | 0.78–2.10 | 0.334 | |||
Chemotherapy treatment characteristics | ||||||
No. of cycles of first line chemotherapy | ||||||
4–6 (vs 1–3) | 0.36 | 0.17–0.74 | 0.005 | 0.21 | 0.09–0.50 | < 0.001 |
Received Platinum based first line chemotherapy | 0.81 | 0.32–2.02 | 0.645 | |||
Received second line chemotherapy | 0.64 | 0.39–1.05 | 0.077 | |||
Received more than two lines of chemotherapy | 0.50 | 0.22–1.11 | 0.087 | |||
Radiotherapy treatment characteristics | ||||||
Received prophylactic cranial irradiation | 0.35 | 0.19–0.65 | 0.001 | 0.22 | 0.10–0.47 | < 0.001 |
Received thoracic radiation | 0.52 | 0.31–0.87 | 0.014 | 0.49 | 0.28–0.86 | 0.013 |
Received whole brain radiation | 0.92 | 0.57–1.49 | 0.742 | 0.32 | 0.17–0.59 | < 0.001 |
Received skeletal radiation | 2.28 | 1.09–4.76 | 0.028 | 0.83 | 0.33–2.13 | 0.704 |