Table 1 Baseline characteristics of patients who had at least stable disease after first line chemotherapy
Characteristic | 2003–2006 (n = 30) | 2007–2010 (n = 41) | P value | ||
|---|---|---|---|---|---|
No. of patients | % | No. of patients | % | ||
Sociodemographic and clinical characteristics | |||||
Age at diagnosis, years | |||||
< 70 | 14 | 46.7 | 20 | 48.8 | 0.860 |
≥ 70 | 16 | 53.3 | 21 | 51.2 | |
Gender | |||||
Male | 25 | 83.3 | 38 | 92.7 | 0.269 |
Female | 5 | 16.7 | 3 | 7.3 | |
ECOG PS | |||||
1 | 21 | 70.0 | 35 | 85.4 | 0.117 |
2–4 | 9 | 30.0 | 6 | 14.6 | |
Smoking status | |||||
Lifetime non-smoker | 1 | 3.3 | 1 | 2.4 | 0.999 |
Ex-smoker | 9 | 30.0 | 13 | 31.7 | |
Smoker | 20 | 66.7 | 27 | 65.9 | |
Charlson’s co-morbidity index | |||||
0 | 16 | 53.3 | 19 | 46.3 | 0.738 |
1–2 | 12 | 40.0 | 20 | 48.8 | |
≥ 3 | 2 | 6.7 | 2 | 4.9 | |
Had brain imaging at diagnosis | 17 | 56.7 | 27 | 65.9 | 0.431 |
Chemotherapy treatment characteristics | |||||
No. of cycles of first line chemotherapy | |||||
1–3 | 5 | 16.7 | 4 | 9.8 | 0.493 |
4–6 | 25 | 83.3 | 34 | 82.9 | |
Not reported | 0 | 0.0 | 3 | 7.3 | |
Received Platinum based first line chemotherapy | 28 | 93.3 | 38 | 92.7 | 0.999 |
Received second line chemotherapy | 5 | 16.7 | 20 | 48.8 | 0.005 |
Received more than two lines of chemotherapy | 1 | 3.3 | 6 | 14.6 | 0.226 |
Radiotherapy treatment characteristics | |||||
Received prophylactic cranial irradiation | 3 | 10.0 | 13 | 31.7 | 0.044 |
Received thoracic radiation | 9 | 33.0 | 16 | 39.0 | 0.432 |
Received whole brain radiation | 12 | 40.0 | 17 | 41.5 | 0.901 |
Received skeletal radiation | 5 | 16.7 | 4 | 9.8 | 0.479 |