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Fig. 4 | Radiation Oncology

Fig. 4

From: Transportable system enabling multiple irradiation studies under simultaneous hypoxia in vitro

Fig. 4

The radiosensitivity of cells treated in Minihypoxy chambers is decreased. a The phosphorylation of H2A.X histone (γH2A.X) marks the double strand breakages on. The γH2A.X level is gradually increased in HeLa cells with dosage in normoxia (21% O2) and in hypoxia preconditioned samples (HW) but in Minihypoxy samples (MH) there is significantly less damage. b Quantification of three independent biological experiments (n = 3). c The western blots showing γH2A.X level in HeLa and UT-SCC74 cells. Representative blot is shown. d The clonogenicity of the HeLa and UT-SCC74 cells is decreased in all conditions but especially in normoxic (21% O2) and in hypoxia preconditioned (HW) samples (HeLa only). Quantification of three independent biological experiments (n = 3)

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