Skip to main content

Table 3 Univariable Cox regression analysis of recurrence

From: Relation of baseline neutrophil-to-lymphocyte ratio to survival and toxicity in head and neck cancer patients treated with (chemo-) radiation

  Univariable analysis
HR (95% CI) P
Loco-regional recurrence (38 events)
 Age per 10 years older 1.08 (0.80–1.48) 0.607
 Gender male vs. female 1.21 (0.53–2.75) 0.648
 Smoking status never smoker (vs. current/past) 1.68 (0.34–8.31) 0.526
 Karnofsky Performance Status KPS over 70 0.55 (0.23–1.35) 0.191
 UICC stage IVA-B (vs. I-III) 3.43 (1.34–8.78) 0.010*
 Tumor grade G3 (vs. G1-G2) 0.78 (0.40–1.53) 0.477
 Hemoglobin per 1 g/dL higher 0.92 (0.76–1.13) 0.424
 log NLR per 1 log NLR higher 1.49 (0.83–2.68) 0.182
 log PLR per 1 log PLR higher 1.65 (0.88–3.10) 0.117
Distant recurrence (20 events)
 Age per 10 years older 0.77 (0.49–1.22) 0.272
 Gender male 2.48 (0.57–10.7) 0.224
 Smoking status never smoker (vs. current/past) 0.04 (0.00–22.86) 0.314
 Karnofsky Performance Status KPS over 70 2.53 (0.34–18.94) 0.367
 UICC stage IV (vs. I-III) 9.91 (1.33–74.03) 0.025*
 Tumor grade G3 (vs. lower) 1.53 (0.64–3.68) 0.342
 Hemoglobin per 1 g/dL higher 1.11 (0.84–1.46) 0.472
 log NLR per 1 log NLR higher 1.38 (0.65–2.91) 0.400
 log PLR per 1 log PLR higher 1.44 (0.65–3.22) 0.371
Any recurrence (46 events)
 Age per 10 years older 1.04 (0.78–1.28) 0.779
 Gender male 1.30 (0.61–2.79) 0.501
 Smoking status never smoker (vs. current/past) 0.60 (014–2.63) 0.501
 Karnofsky Performance Status KPS over 70 0.74 (0.33–1.65) 0.457
 Localization larynx or hypopharynx (vs. other) 1.24 (0.66–2.33) 0.497
 UICC stage IV (vs. I-III) 3.49 (1.48–8.24) 0.004*
 Tumor grade G3 (vs. G1-G2) 0.96 (0.53–1.74) 0.891
 Hemoglobin per 1 g/dL higher 0.95 (0.79–1.14) 0.948
 log NLR per 1 log NLR higher 1.49 (0.88–2.53) 0.134
 log PLR per 1 log PLR higher 1.55 (0.88–2.74) 0.128
  1. CI confidence interval, G tumor grade, HR hazard ratio, log NLR natural logarithm of neutrophil-to-lymphocyte ratio, log PLR natural logarithm of platelet-to-lymphocyte ratio, UICC Union for International Cancer Control; *statistically significant