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Table 3 Univariable Cox regression analysis of recurrence

From: Relation of baseline neutrophil-to-lymphocyte ratio to survival and toxicity in head and neck cancer patients treated with (chemo-) radiation

 

Univariable analysis

HR (95% CI)

P

Loco-regional recurrence (38 events)

 Age

per 10 years older

1.08 (0.80–1.48)

0.607

 Gender

male vs. female

1.21 (0.53–2.75)

0.648

 Smoking status

never smoker (vs. current/past)

1.68 (0.34–8.31)

0.526

 Karnofsky Performance Status

KPS over 70

0.55 (0.23–1.35)

0.191

 UICC stage

IVA-B (vs. I-III)

3.43 (1.34–8.78)

0.010*

 Tumor grade

G3 (vs. G1-G2)

0.78 (0.40–1.53)

0.477

 Hemoglobin

per 1 g/dL higher

0.92 (0.76–1.13)

0.424

 log NLR

per 1 log NLR higher

1.49 (0.83–2.68)

0.182

 log PLR

per 1 log PLR higher

1.65 (0.88–3.10)

0.117

Distant recurrence (20 events)

 Age

per 10 years older

0.77 (0.49–1.22)

0.272

 Gender

male

2.48 (0.57–10.7)

0.224

 Smoking status

never smoker (vs. current/past)

0.04 (0.00–22.86)

0.314

 Karnofsky Performance Status

KPS over 70

2.53 (0.34–18.94)

0.367

 UICC stage

IV (vs. I-III)

9.91 (1.33–74.03)

0.025*

 Tumor grade

G3 (vs. lower)

1.53 (0.64–3.68)

0.342

 Hemoglobin

per 1 g/dL higher

1.11 (0.84–1.46)

0.472

 log NLR

per 1 log NLR higher

1.38 (0.65–2.91)

0.400

 log PLR

per 1 log PLR higher

1.44 (0.65–3.22)

0.371

Any recurrence (46 events)

 Age

per 10 years older

1.04 (0.78–1.28)

0.779

 Gender

male

1.30 (0.61–2.79)

0.501

 Smoking status

never smoker (vs. current/past)

0.60 (014–2.63)

0.501

 Karnofsky Performance Status

KPS over 70

0.74 (0.33–1.65)

0.457

 Localization

larynx or hypopharynx (vs. other)

1.24 (0.66–2.33)

0.497

 UICC stage

IV (vs. I-III)

3.49 (1.48–8.24)

0.004*

 Tumor grade

G3 (vs. G1-G2)

0.96 (0.53–1.74)

0.891

 Hemoglobin

per 1 g/dL higher

0.95 (0.79–1.14)

0.948

 log NLR

per 1 log NLR higher

1.49 (0.88–2.53)

0.134

 log PLR

per 1 log PLR higher

1.55 (0.88–2.74)

0.128

  1. CI confidence interval, G tumor grade, HR hazard ratio, log NLR natural logarithm of neutrophil-to-lymphocyte ratio, log PLR natural logarithm of platelet-to-lymphocyte ratio, UICC Union for International Cancer Control; *statistically significant