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Table 2 Univariable and multivariable Cox regression analysis of overall survival

From: Relation of baseline neutrophil-to-lymphocyte ratio to survival and toxicity in head and neck cancer patients treated with (chemo-) radiation

 

univariable analysis

multivariable analysis

HR (95% CI)

P

HR (95% CI)

P

Age

per 10 years older

1.32 (1.03–1.69)

0.026*

  

Gender

male (vs. female)

1.17 (0.61–2.25)

0.639

  

Smoking status

never smoker (vs. current/past)

0.66 (0.20–2.19)

0.492

  

Karnofsky Performance Status

per 10 higher

0.76 (0.62–0.92)

0.005*

0.76 (0.62–0.98)

0.030*

UICC stage

IVA-B (vs. I-III)

1.87 (1.01–3.47)

0.045*

  

Tumor grade

G3 (vs. G1-G2)

0.91 (0.54–1.54)

0.731

  

Hemoglobin

per 1 g/dL higher

0.89 (0.77–1.04)

0.143

  

log NLR

per 1 log NLR higher

1.81 (1.16–2.81)

0.009*

1.58 (1.01–2.47)

0.043*

log PLR

per 1 log PLR higher

1.62 (0.99–2.63)

0.054

  
  1. CI confidence interval, G tumor grade, HR hazard ratio, log NLR natural logarithm of neutrophil-to-lymphocyte ratio, log PLR natural logarithm of platelet-to-lymphocyte ratio, UICC Union for International Cancer Control; *statistically significant