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Table 5 Cox UVA and MVA for the total cohort

From: Dose escalation of radiation therapy with or without induction chemotherapy for unresectable locally advanced pancreatic cancer

Variable

Cox UVA

Cox MVA

HR

95% CI

P

HR

95% CI

P

Facility

 Nonacademic

1

Ref

 

1

Ref

 

 Academic

0.80

0.73–0.88

< 0.001

0.90

0.81–0.99

0.036

Age

 < 65

1

Ref

 

1

Ref

 

 ≥ 65

1.15

1.05–1.26

0.0027

1.18

1.07–1.30

0.0013

Gender

 Female

1

Ref

 

1

Ref

 

 Male

1.11

1.01–1.22

0.024

1.08

0.98–1.19

0.13

Race

 White

1

Ref

    

 Black

0.96

0.85–1.10

0.58

   

 Other

0.89

0.66–1.20

0.43

   

Insurance

 None

1

Ref

    

 Nonprivate

1.20

0.88–1.62

0.25

   

Private

1.02

0.75–1.38

0.91

   

Income

 Above median

1

Ref

 

1

Ref

 

 Below median

1.22

1.11–1.34

< 0.001

1.20

1.08–1.32

< 0.001

Residential setting

 Metro

1

Ref

    

 Urban

1.07

0.95–1.21

0.27

   

 Rural

1.25

0.96–1.64

0.10

   

Charlson-Deyo Score

 0–1

1

Ref

    

 ≥ 2

1.06

0.86–1.30

0.61

   

Year of diagnosis

 2004–2007

1

Ref

 

1

Ref

 

 2008–2011

0.85

0.76–0.95

0.0045

0.92

0.81–1.05

0.20

 2012–2015

0.62

0.55–0.71

< 0.001

0.77

0.66–0.89

< 0.001

Primary tumor site

 Head

1

Ref

    

 Body

0.92

0.83–1.01

0.088

   

 Tail

1.13

0.87–1.48

0.35

   

Tumor size (cm)

 < 3.8

1

Ref

 

1

Ref

 

 ≥ 3.8

1.11

1.01–1.22

0.035

1.15

1.04–1.27

0.0049

Clinical N stage

 0

1

Ref

    

 1

1.08

0.99–1.19

0.098

   

Chemotherapy

 Single agent

1

Ref

 

1

Ref

 

 Multi agent

0.63

0.57–0.69

< 0.001

0.78

0.69–0.87

< 0.001

Induction chemotherapy

 No

1

Ref

 

1

Ref

 

 Yes

0.58

0.53–0.64

< 0.001

0.73

0.65–0.83

< 0.001

Dose escalation

 < 55 Gy

1

Ref

 

1

Ref

 

 ≥ 55 Gy

0.86

0.76–0.97

0.012

0.87

0.76–0.99

0.029

  1. UVA univariate analysis, MVA multivariable analysis, HR hazard ratio, CI confidence interval, Ref reference
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Radiation Oncology

ISSN: 1748-717X

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