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Table 4 Cox UVA and MVA for cohort CRT

From: Dose escalation of radiation therapy with or without induction chemotherapy for unresectable locally advanced pancreatic cancer

Variable

Cox UVA

Cox MVA

HR

95% CI

P

HR

95% CI

P

Facility

 Nonacademic

1

Ref

 

1

Ref

 

 Academic

0.89

0.79–0.997

0.045

0.91

0.81–1.03

0.14

Age

 < 65

1

Ref

 

1

Ref

 

 ≥ 65

1.18

1.06–1.32

0.0038

1.18

1.05–1.32

0.0055

Gender

 Female

1

Ref

    

 Male

1.05

0.94–1.17

0.44

   

Race

 White

1

Ref

    

 Black

0.99

0.85–1.16

0.91

   

 Other

0.99

0.67–1.48

0.98

   

Insurance

 None

1

Ref

    

 Nonprivate

1.33

0.94–1.88

0.11

   

 Private

1.09

0.77–1.55

0.63

   

Income

 Above median

1

Ref

 

1

Ref

 

 Below median

1.21

1.08–1.36

< 0.001

1.21

1.08–1.36

< 0.001

Residential setting

 Metro

1

Ref

    

 Urban

1.02

0.88–1.17

0.83

   

 Rural

1.14

0.83–1.56

0.43

   

Charlson-Deyo Score

     

 0–1

1

Ref

    

 ≥ 2

1.01

0.78–1.30

0.94

   

Year of diagnosis

 2004–2007

1

Ref

    

 2008–2011

0.92

0.81–1.04

0.19

   

 2012–2015

0.91

0.77–1.07

0.25

   

Primary tumor site

 Head

1

Ref

    

 Body

0.96

0.85–1.09

0.57

   

 Tail

1.04

0.76–1.43

0.80

   

Tumor size (cm)

 < 3.8

1

Ref

    

 ≥ 3.8

1.08

0.96–1.21

0.22

   

Clinical N stage

 0

1

Ref

    

 1

1.09

0.97–1.22

0.17

   

Chemotherapy

 Single agent

1

Ref

 

1

Ref

 

 Multi agent

0.79

0.70–0.90

< 0.001

0.81

0.71–0.92

0.0016

Dose escalation

 < 55 Gy

1

Ref

    

 ≥ 55 Gy

0.91

0.78–1.05

0.19

   
  1. UVA univariate analysis, MVA multivariable analysis, HR hazard ratio, CI confidence interval, Ref reference
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Radiation Oncology

ISSN: 1748-717X

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