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Table 2 Cox UVA and MVA for cohort iC + CRT

From: Dose escalation of radiation therapy with or without induction chemotherapy for unresectable locally advanced pancreatic cancer

Variable

Cox UVA

Cox MVA

HR

95% CI

P

HR

95% CI

P

Facility

 Nonacademic

1

Ref

 

1

Ref

 

 Academic

0.76

0.65–0.89

< 0.001

0.79

0.67–0.93

0.0045

Age

 < 65

1

Ref

    

 ≥ 65

1.04

0.89–1.21

0.64

   

Gender

 Female

1

Ref

 

1

Ref

 

 Male

1.19

1.02–1.39

0.031

1.09

0.93–1.29

0.29

Race

 White

1

Ref

    

 Black

0.86

0.68–1.10

0.23

   

 Other

0.86

0.54–1.36

0.52

   

Insurance

 None

1

Ref

    

 Nonprivate

1.07

0.57–2.02

0.82

   

 Private

1.07

0.57–2.01

0.83

   

Income

 Above median

1

Ref

    

 Below median

1.05

0.90–1.24

0.52

   

Residential setting

 Metro

1

Ref

    

 Urban

1.00

0.79–1.26

0.98

   

 Rural

1.35

0.80–2.25

0.26

   

Charlson-Deyo Score

 0–1

1

Ref

    

 ≥ 2

1.08

0.75–1.57

0.67

   

Year of diagnosis

 2004–2007

1

Ref

 

1

Ref

 

 2008–2011

0.95

0.71–1.28

0.75

   

 2012–2015

0.67

0.50–0.89

0.0068

0.71

0.53–0.95

0.021

Primary tumor site

 Head

1

Ref

    

 Body

0.87

0.73–1.04

0.12

   

 Tail

1.25

0.78–2.01

0.35

   

Tumor size (cm)

 < 3.8

1

Ref

 

1

Ref

 

 ≥ 3.8

1.20

1.02–1.41

0.027

1.16

0.98–1.37

0.082

Clinical N stage

 0

1

Ref

    

 1

1.15

0.98–1.34

0.091

   

Chemotherapy

 Single agent

1

Ref

 

1

Ref

 

 Multi agent

0.69

0.58–0.82

< 0.001

0.77

0.64–0.92

0.0041

Dose escalation

 < 55 Gy

1

Ref

 

1

Ref

 

 ≥ 55 Gy

0.80

0.65–0.97

0.027

0.77

0.63–0.95

0.013

  1. UVA univariate analysis, MVA multivariable analysis, HR hazard ratio, CI confidence interval, Ref reference
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