Radiation Oncology

Table 1 Baseline characteristics, before matching

From: Dose escalation of radiation therapy with or without induction chemotherapy for unresectable locally advanced pancreatic cancer

	Cohort iC + CRT					Cohort CRT
	45–55 Gy		55+ Gy			45–55 Gy		55+ Gy
	N	%	N	%	P	N	%	N	%	P
Facility					0.39					0.0031
Nonacademic	335	56	71	52		672	63	163	72
Academic	259	43	65	47		390	37	58	26
NA	7	1	1	1		4	0	4	2
Age					1					0.0081
< 65	303	50	69	50		474	44	122	54
≥ 65	298	50	68	50		592	56	103	46
NA	0	0	0	0		0	0	0	0
Gender					0.047					1
Female	297	49	81	59		514	48	109	48
Male	304	51	56	41		552	52	116	52
NA	0	0	0	0		0	0	0	0
Race					0.88					0.18
White	493	82	115	84		869	82	190	84
Black	81	13	17	12		168	16	27	12
Other	19	3	3	2		20	2	7	3
NA	8	1	2	1		9	1	1	0
Insurance					0.31					0.095
None	12	2	2	1		28	3	7	3
Nonprivate	320	53	63	46		633	59	117	52
Private	265	44	70	51		391	37	99	44
NA	4	1	2	1		14	1	2	1
Income					1					0.45
Above median	389	65	90	66		546	51	118	52
Below median	207	34	47	34		503	47	97	43
NA	5	1	0	0		17	2	10	4
Residential setting					0.33					0.077
Metro	488	81	114	83		807	76	151	67
Urban	77	13	16	12		189	18	53	24
Rural	10	2	5	4		34	3	7	3
NA	26	4	2	1		36	3	14	6
Charlson-Deyo Score					1					0.25
0–1	575	96	131	96		1006	94	217	96
≥ 2	26	4	6	4		60	6	8	4
NA	0	0	0	0		0	0	0	0
Year of diagnosis					0.016					< 0.001
2004–2007	52	9	7	5		317	30	92	41
2008–2011	245	41	74	54		529	50	105	47
2012–2015	304	51	56	41		220	21	28	12
NA	0	0	0	0		0	0	0	0
Primary tumor site					0.068					0.014
Head	411	68	94	69		764	72	140	62
Body	171	28	43	31		271	25	74	33
Tail	19	3	0	0		31	3	11	5
NA	0	0	0	0		0	0	0	0
Tumor size (cm)					0.70					0.018
< 3.8	265	44	65	47		486	46	82	36
≥ 3.8	283	47	64	47		448	42	111	49
NA	53	9	8	6		132	12	32	14
Clinical N stage					0.44					0.70
0	367	61	89	65		692	65	143	64
1	234	39	48	35		374	35	82	36
NA	0	0	0	0		0	0	0	0
Chemotherapy					0.20					0.74
Single agent	166	28	30	22		789	74	164	73
Multi agent	435	72	107	78		277	26	61	27
NA	0	0	0	0		0	0	0	0
Total radiation dose (Gy)					< 0.001					< 0.001
Median	50.4		59.4			50.4		59.4
IQR	50.4–52.5		56.0–59.4			50.4–52.0		57.5–60.0
Fraction					< 0.001					< 0.001
Median	28		30			28		32
IQR	27–28		28–33			26–28		30–33

iC induction chemotherapy, CRT chemoradiation, IQR interquartile range, NA not available

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